Bootstrapping for Pharmacokinetic Models: Visualization of Predictive and Parameter Uncertainty

被引：0

作者：

C. Anthony Hunt

Geof H. Givens

Serge Guzy

机构：

[1] University of California,Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, and The Programs Bioengineering and Medical Information Science

[2] Colorado State University,Department of Statistics

[3] University of California,Department of Clinical Pharmacy

来源：

Pharmaceutical Research | 1998年 / 15卷

关键词：

pharmacokinetic; predict; model; parameter; bootstrap; forecast; algorithm; estimates; simulate; decision support; pharmacometrics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Purpose. We explore use of "bootstrapping” methods to obtain a measure of reliability of predictions made in part from fits of individual drug level data with a pharmacokinetic (PK) model, and to help clarify parameter identifiability for such models.

引用

页码：690 / 697

页数：7

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