Bootstrapping for Pharmacokinetic Models: Visualization of Predictive and Parameter Uncertainty

被引：0
|
作者：
C. Anthony Hunt
Geof H. Givens
Serge Guzy
机构：
[1] University of California,Departments of Biopharmaceutical Sciences and Pharmaceutical Chemistry, and The Programs Bioengineering and Medical Information Science
[2] Colorado State University,Department of Statistics
[3] University of California,Department of Clinical Pharmacy
来源：
Pharmaceutical Research | 1998年 / 15卷
关键词：
pharmacokinetic; predict; model; parameter; bootstrap; forecast; algorithm; estimates; simulate; decision support; pharmacometrics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. We explore use of "bootstrapping” methods to obtain a measure of reliability of predictions made in part from fits of individual drug level data with a pharmacokinetic (PK) model, and to help clarify parameter identifiability for such models.
引用
收藏
页码：690 / 697
页数：7
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