Multi-state models provide a convenient statistical framework for a wide variety of medical applications characterized by multiple events and longitudinal data. We illustrate this through four examples. The potential value of the incorporation of unobserved or partially observed states is highlighted. In addition, joint modelling of multiple processes is illustrated with application to potentially informative loss to follow-up, mis-measured or missclassified data and causal inference.
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Dell Int Serv India Pvt Ltd, 12-2-A,13-1-A,Inner Ring Rd, Bangalore 560071, Karnataka, IndiaDell Int Serv India Pvt Ltd, 12-2-A,13-1-A,Inner Ring Rd, Bangalore 560071, Karnataka, India
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Univ Minho, Dept Math Sci & Technol, Campus Azurem, P-4800058 Guimaraes, PortugalUniv Minho, Dept Math Sci & Technol, Campus Azurem, P-4800058 Guimaraes, Portugal
Meira-Machado, Luis
Cadarso-Suarez, Carmen
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Univ Santiago Compostela, Dept Stat & Operat Res, La Coruna, SpainUniv Minho, Dept Math Sci & Technol, Campus Azurem, P-4800058 Guimaraes, Portugal
Cadarso-Suarez, Carmen
Una-Alvarez, Jacobo
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Univ Vigo, Dept Stat & Operat Res, Vigo, SpainUniv Minho, Dept Math Sci & Technol, Campus Azurem, P-4800058 Guimaraes, Portugal