Active DNA demethylation at enhancers during the vertebrate phylotypic period

被引：0

作者：

Ozren Bogdanović

Arne H Smits

Elisa de la Calle Mustienes

Juan J Tena

Ethan Ford

Ruth Williams

Upeka Senanayake

Matthew D Schultz

Saartje Hontelez

Ila van Kruijsbergen

Teresa Rayon

Felix Gnerlich

Thomas Carell

Gert Jan C Veenstra

Miguel Manzanares

Tatjana Sauka-Spengler

Joseph R Ecker

Michiel Vermeulen

José Luis Gómez-Skarmeta

Ryan Lister

机构：

[1] Australian Research Council Centre of Excellence in Plant Energy Biology,Department of Molecular Biology

[2] University of Western Australia,Department of Molecular Developmental Biology

[3] Centro Andaluz de Biología del Desarrollo,undefined

[4] Consejo Superior de Investigaciones Científicas,undefined

[5] Universidad Pablo de Olavide,undefined

[6] Harry Perkins Institute of Medical Research,undefined

[7] Faculty of Science,undefined

[8] Radboud Institute for Molecular Life Sciences,undefined

[9] Radboud University,undefined

[10] Weatherall Institute of Molecular Medicine,undefined

[11] University of Oxford,undefined

[12] Genomic Analysis Laboratory,undefined

[13] Salk Institute for Biological Studies,undefined

[14] Faculty of Science,undefined

[15] Radboud Institute for Molecular Life Sciences,undefined

[16] Radboud University,undefined

[17] Centro Nacional de Investigaciones Cardiovasculares,undefined

[18] Centre for Integrated Protein Science,undefined

[19] Ludwig Maximilians Universität München,undefined

[20] Howard Hughes Medical Institute,undefined

[21] Salk Institute for Biological Studies,undefined

来源：

Nature Genetics | 2016年 / 48卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Ozren Bogdanović, Ryan Lister, José Luis Gómez-Skarmeta, Michiel Vermeulen and colleagues report widespread DNA demethylation at developmental enhancers during the phylotypic period in zebrafish, Xenopus and mouse embryos. Their findings suggest a conserved role for Tet proteins and active DNA demethylation in the regulation of phylotypic enhancers.

引用

页码：417 / 426

页数：9

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