Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

被引：0

作者：

Hendrik Poeck

Michael Bscheider

Olaf Gross

Katrin Finger

Susanne Roth

Manuele Rebsamen

Nicole Hannesschläger

Martin Schlee

Simon Rothenfusser

Winfried Barchet

Hiroki Kato

Shizuo Akira

Satoshi Inoue

Stefan Endres

Christian Peschel

Gunther Hartmann

Veit Hornung

Jürgen Ruland

机构：

[1] III. Medizinische Klinik,Center of Integrated Protein Science Munich and Division of Clinical Pharmacology, Department of Internal Medicine

[2] Klinikum rechts der Isar,Department of Biochemistry

[3] Technische Universität München,Department of Host Defense

[4] Institute of Clinical Chemistry and Pharmacology,Department of Geriatric Medicine

[5] Universitätsklinikum Bonn,undefined

[6] University of Munich,undefined

[7] Laboratory of Signaling in the Immune System,undefined

[8] Helmholtz-Zentrum München–Germany,undefined

[9] Research Center for Environmental Health,undefined

[10] University of Lausanne,undefined

[11] Research Institute for Microbial Diseases,undefined

[12] Osaka University,undefined

[13] Graduate School of Medicine,undefined

[14] The University of Tokyo,undefined

[15] Research Center for Genomic Medicine,undefined

[16] Saitama Medical School,undefined

[17] Present address: Department of Biochemistry,undefined

[18] University of Lausanne,undefined

[19] Epalinges,undefined

[20] Switzerland.,undefined

来源：

Nature Immunology | 2010年 / 11卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Production of mature interleukin 1β (IL-1β) requires Il1b transcription and inflammasome-mediated processing of IL-1β protein. Ruland and colleagues show that the RNA virus sensor RIG-I signals via the adaptors CARD9 and Asc to facilitate both processes.

引用

页码：63 / 69

页数：6

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