GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility

被引:0
|
作者
Norma C Salazar
Ximena Vallejos
Ashley Siryk
Giuseppe Rengo
Alessandro Cannavo
Daniela Liccardo
Claudio De Lucia
Erhe Gao
Dario Leosco
Walter J Koch
Anastasios Lymperopoulos
机构
[1] Nova Southeastern University College of Pharmacy,Department of Pharmaceutical Sciences, Laboratory for the Study of Neurohormonal Control of the Circulation
[2] University “Federico II“,Division of Cardiology, Department of Internal Medicine, Cardiovascular Sciences and Immunology
[3] Temple University,Center for Translational Medicine
关键词
Cardiac β; –adrenergic receptor; Pro-contractile signaling; Post-myocardial infarction survival; GRK2 inhibition; GRK5;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Real-time measurements of the interaction of GRK2 with the α2A-adrenergic receptor and Gβγ
    Krasel, C.
    Prokopets, O.
    Zindel, D.
    Buenemann, M.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 : S44 - S44
  • [32] PI3KC2α controls cardiac contractility through regulation of β2-adrenergic receptor recycling
    Cnudde, Sophie
    Brand, Theresa
    Fender, Julia
    Prever, Lorenzo
    Murabito, Alessandra
    Russo, Michele
    Logrand, Federica
    Gulluni, Federico
    Lorenz, Kristina
    Hirsch, Emilio
    Ghigo, Alessandra
    VASCULAR PHARMACOLOGY, 2024, 155 : 107313
  • [33] Phosphorylation of the β2-Adrenergic receptor in plasma membranes by intrinsic GRK5
    Tran, Tuan M.
    Jorgensen, Rasmus
    Clark, Richard B.
    BIOCHEMISTRY, 2007, 46 (50) : 14438 - 14449
  • [34] Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5
    Komolov, Konstantin E.
    Du, Yang
    Nguyen Minh Duc
    Betz, Robin M.
    Rodrigues, Joao P. G. L. M.
    Leib, Ryan D.
    Patra, Dhabaleswar
    Skiniotis, Georgios
    Adams, Christopher M.
    Dror, Ron O.
    Chung, Ka Young
    Kobilka, Brian K.
    Benovic, Jeffrey L.
    CELL, 2017, 169 (03) : 407 - +
  • [35] Clathrin is essential for activation of G protein-coupled receptor kinases 2 (GRK2)
    Mangmool, S
    Haga, T
    Nishida, M
    Kurose, H
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006, 100 : 125P - 125P
  • [36] Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway β2-adrenergic receptor physiologic signaling
    Wang, Wayne C. H.
    Mihlbachler, Kathryn A.
    Brunnett, Alicyn C.
    Liggett, Stephen B.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (35) : 15007 - 15012
  • [37] β2-adrenergic receptor blockade accelerates burn wound healing
    Sivamani, R. K.
    Pullar, C. E.
    Griffths, B.
    Baier, B. S.
    Greenhalgh, D. G.
    Isseroff, R. R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 : 59 - 59
  • [38] Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling following Ischemia/Reperfusion Injury
    Woodall, Meryl C.
    Woodall, Benjamin P.
    Gao Erhe
    Shang Xiying
    Yuan Ancai
    Ibetti, Jessica
    Koch, Walter J.
    CIRCULATION RESEARCH, 2014, 115
  • [39] Osteopontin Mediates Aldosterone-dependent Cardiac Fibrosis Via GRK2-dependent β2-Adrenergic Receptor Dysfunction
    Lymperopoulos, Anastasios
    Pollard, Celina
    Cora, Natalie
    Perez, Arianna
    Noa, Daniela Pi
    Ghandour, Jennifer
    Shehadeh, Lina
    Aukszi, Beatrix
    Valiente, Rachel
    BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 (02) : 418 - 418
  • [40] Insights into signaling from the β2-adrenergic receptor structure
    Audet, Martin
    Bouvier, Michel
    NATURE CHEMICAL BIOLOGY, 2008, 4 (07) : 397 - 403