Lysosome positioning coordinates mTORC1 activity and autophagy

被引：0

作者：

Christian Poüs

Patrice Codogno

机构：

[1] Christian Poüs and Patrice Codogno are at the Université Paris-Sud 11,

[2] IFR 141,undefined

[3] Faculté de Pharmacie,undefined

[4] 92296 Châtenay-Malabry,undefined

[5] France.,undefined

[6] Christian Poüs is also at the Université Paris-Sud 11,undefined

[7] EA 4530,undefined

[8] Faculté de Pharmacie,undefined

[9] 92296 Châtenay-Malabry,undefined

[10] France,undefined

[11] Patrice Codogno is also at INSERM UMR984,undefined

[12] 92296 Châtenay-Malabry,undefined

[13] France.,undefined

来源：

Nature Cell Biology | 2011年 / 13卷

关键词：

D O I：

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学科分类号：

摘要：

Under nutrient-rich conditions, the nutrient-sensitive kinase mTOR (mammalian target of rapamycin) is recruited to the surface of lysosomes where it becomes activated and can promote cell growth and inhibit autophagy. In contrast, mTOR is inhibited in nutrient-poor conditions, leading to the induction of autophagy. The intracellular positioning of lysosomes in response to nutrient availability is now shown to orchestrate mTOR activation and regulate autophagy.

引用

页码：342 / 344

页数：2

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