Autophagy maintains stemness by preventing senescence

被引：0
|
作者：
Laura García-Prat
Marta Martínez-Vicente
Eusebio Perdiguero
Laura Ortet
Javier Rodríguez-Ubreva
Elena Rebollo
Vanessa Ruiz-Bonilla
Susana Gutarra
Esteban Ballestar
Antonio L. Serrano
Marco Sandri
Pura Muñoz-Cánoves
机构：
[1] Cell Biology Group,Department of Experimental and Health Sciences
[2] Pompeu Fabra University (UPF),Department of Biomedical Science
[3] CIBER on Neurodegenerative diseases (CIBERNED),undefined
[4] Neurodegenerative Diseases Research Group,undefined
[5] Vall d’Hebron Research Institute-CIBERNED,undefined
[6] Chromatin and Disease Group,undefined
[7] Cancer Epigenetics and Biology Programme (PEBC),undefined
[8] Bellvitge Biomedical Research Institute (IDIBELL),undefined
[9] L’Hospitalet de Llobregat,undefined
[10] Advanced Fluorescence Microscopy Unit,undefined
[11] Molecular Biology Institute of Barcelona (IBMB-CSIC),undefined
[12] University of Padova,undefined
[13] Telethon Institute of Genetics and Medicine (TIGEM),undefined
[14] ICREA,undefined
来源：
Nature | 2016年 / 529卷
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摘要：
The regenerative properties of muscle stem cells decline with age as the stem cells enter an irreversible state of senescence; a study of mouse muscle stem cells reveals that entry into senescence is an autophagy-dependent process and promoting autophagy in old satellite cells can reverse senescence and restore their regenerative properties in an injury model.
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页码：37 / 42
页数：5
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