Synthesis of 7-alkyl-4-amino-7H-pyrrolo-[2,3-d]pyrimidine-6-carboxylic acids

被引：0
|
作者：
E. V. Verves
A. V. Kucher
L. V. Muzychka
O. B. Smolii
机构：
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
来源：
Chemistry of Heterocyclic Compounds | 2013年 / 48卷
关键词：
ethyl ; -alkylglycinate; pyrimido[5',4':4,5]pyrrolo[2,1-; ][1,4]oxazine; 7; -pyrrolo[2,3-; ]-pyrimidine; cyclization;
D O I：
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摘要：
Two variants are discussed for the synthesis of ethyl N-alkyl-N-(6-amino-5-formylpyrimidin-4-yl)-glycinate derivatives, which are converted by intramolecular cyclization under the influence of sodium methoxide to give methyl 7H-pyrrolo[2,3-d]pyrimidine-6-carboxylates. New derivatives of pyrimido- [5',4':4,5]pyrrolo[2,1-c][1,4]oxazines containing 3-chloropropyl groups at position 8 have been prepared.
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页码：1844 / 1852
页数：8
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