Synthesis and evaluation of the hypoglycemic and hypolipidemic activity of novel 5-benzylidene-2,4-thiazolidinedione analogs in a type-2 diabetes model

被引：0
|
作者：
Sonali Mehendale-Munj
Rumi Ghosh
C. S. Ramaa
机构：
[1] Bharati Vidyapeeth’s College of Pharmacy,Department of Pharmaceutical Chemistry
[2] Bharati Vidyapeeth’s College of Pharmacy,Department of Pharmacology
来源：
Medicinal Chemistry Research | 2011年 / 20卷
关键词：
Type-2 diabetes; 5-Benzylidene-2,4-thiazolidinedione; Knoevenagel condensation; Hypoglycemic activity; Streptozotocin;
D O I：
暂无
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学科分类号：
摘要：
This article reports synthesis and evaluation of two novel thiazolidinedione ring containing molecules namely (Z)-5-(2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetyl)-2-hydroxybenzamide (4) and (Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(5-nitrothiazol-2-yl)acetamide (7). The new chemical entities were tested for hypoglycemic activity and for their total cholesterol (CHL) and triglyceride (TG) lowering effect in high-fat diet (HFD) fed Sprague–Dawley rats. The synthesized molecules showed significant reduction in blood glucose, CHL, and TG levels after 14 days of treatment.
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页码：642 / 647
页数：5
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