Synthesis and evaluation of the hypoglycemic and hypolipidemic activity of novel 5-benzylidene-2,4-thiazolidinedione analogs in a type-2 diabetes model

被引：0

作者：

Sonali Mehendale-Munj

Rumi Ghosh

C. S. Ramaa

机构：

[1] Bharati Vidyapeeth’s College of Pharmacy,Department of Pharmaceutical Chemistry

[2] Bharati Vidyapeeth’s College of Pharmacy,Department of Pharmacology

来源：

Medicinal Chemistry Research | 2011年 / 20卷

关键词：

Type-2 diabetes; 5-Benzylidene-2,4-thiazolidinedione; Knoevenagel condensation; Hypoglycemic activity; Streptozotocin;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This article reports synthesis and evaluation of two novel thiazolidinedione ring containing molecules namely (Z)-5-(2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetyl)-2-hydroxybenzamide (4) and (Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(5-nitrothiazol-2-yl)acetamide (7). The new chemical entities were tested for hypoglycemic activity and for their total cholesterol (CHL) and triglyceride (TG) lowering effect in high-fat diet (HFD) fed Sprague–Dawley rats. The synthesized molecules showed significant reduction in blood glucose, CHL, and TG levels after 14 days of treatment.

引用

页码：642 / 647

页数：5

共 38 条

[1] Synthesis and evaluation of the hypoglycemic and hypolipidemic activity of novel 5-benzylidene-2,4-thiazolidinedione analogs in a type-2 diabetes model
Mehendale-Munj, Sonali
Ghosh, Rumi
Ramaa, C. S.
MEDICINAL CHEMISTRY RESEARCH, 2011, 20 (05) : 642 - 647
[2] Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Novel Arylidene Thiazolidinedione Analogson a Type 2 Diabetes Model
Ahmadi, Abbas
Khalili, Mohsen
Samavat, Simin
Shahbazi, Elnaz
Nahri-Niknafs, Babak
PHARMACEUTICAL CHEMISTRY JOURNAL, 2016, 50 (03) : 165 - 171
[3] Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Novel Arylidene Thiazolidinedione Analogson a Type 2 Diabetes Model
Abbas Ahmadi
Mohsen Khalili
Simin Samavat
Elnaz Shahbazi
Babak Nahri-Niknafs
Pharmaceutical Chemistry Journal, 2016, 50 : 165 - 171
[4] Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2, 4-thiazolidinedione derivatives
Patil, Vijay
Tilekar, Kalpana
Mehendale-Munj, Sonali
Mohan, Rhea
Ramaa, C. S.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (10) : 4539 - 4544
[5] Hypoglycemic and Hypolipidemic Swords: Synthesis and In-vivo Biological Assessment of 5-benzylidene-2,4-thiazolidinediones
Patil, Vijay
Upadhyay, Neha
Tilekar, Kalpana
Joshi, Hardik
Ramaa, C. S.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2021, 20 (04): : 188 - 201
[6] Synthesis and Biological Evaluation of Novel 2,4-Thiazolidinedione Derivatives as Antibacterial Agent
Patil, A. M.
Sayare, A. S.
Chitlange, S. S.
Khadke, A. P.
Pokharkar, D. V.
ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (11) : 5305 - 5308
[7] Synthesis and antiedematogenic activity of some N-trypthophyl-5-benzylidene-2,4-thiazolidinedione and N-trypthophyl-5-benzylidene-rhodanine derivatives
Góes, AJD
de Lima, WT
Nagy, HJ
Alves, AJ
de Faria, AR
de Lima, JG
Maia, MBD
QUIMICA NOVA, 2004, 27 (06): : 905 - 910
[8] Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring
Bozdag-Dundar, Oya
Ceylan-Unlusoy, Meltern
Verspohl, Eugen J.
Ertan, Rahmiye
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2006, 56 (09): : 621 - 625
[9] Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione
Kim, BY
Ahn, JB
Lee, HW
Kang, SK
Lee, JH
Shin, JS
Ahn, SK
Hong, CI
Yoon, SS
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (05) : 433 - 447
[10] Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4-thiazolidnedione
Ahmadi, Abbas
Khalili, Mohsen
Sohrabi, Lida
Delzendeh, Nazanin
Nahri-Niknafs, Babak
Ansari, Fariba
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2017, 17 (08) : 721 - 726

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