Directing evolution: the next revolution in drug discovery?

被引：0
|
作者：
Andrew M. Davis
Alleyn T. Plowright
Eric Valeur
机构：
[1] AstraZeneca R&D Gothenburg,
[2] Integrated Drug Discovery,undefined
[3] Sanofi-Aventis Deutschland GmbH,undefined
来源：
Nature Reviews Drug Discovery | 2017年 / 16卷
关键词：
D O I：
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学科分类号：
摘要：
Recent advances in areas such as natural product biosynthesis, synthetic biology and the development of biosensors are providing new opportunities to directly harness evolutionary pressure to identify and optimize compounds with desired bioactivities. This article describes innovations in the key components of such strategies, highlights pioneering examples that indicate their potential, and discusses the scientific gaps and challenges that remain to be addressed to realize this potential more broadly in drug discovery.
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页码：681 / 698
页数：17
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