Polymorphism rs1046495 of the GFER Gene as a New Genetic Marker of Preposition to Type 2 Diabetes Mellitus

The study involving 2830 subjects (1444 patients with type 2 diabetes mellitus and 1386 healthy controls) an association of the rs1046495 polymorphism of the GFER gene encoding FADdependent sulfhydryl oxidase with low risk of the disease in non-obese patients (OR=0.76, 95%CI 0.57-0.99, p=0.029). The protective effect of the polymorphic gene variant remained significant in individuals who consumed fresh vegetables and fruits (p=0.014), proteins (p=0.0017), and did not consume carbohydrate- and fat-reach food (p=0.0047). The association of the minor allele rs1046495-C with type 2 diabetes mellitus can be explained by its more pronounced effect on the expression of the GFER enzyme that through glutathionation maintains the ROS level for optimal functioning of complexes III and IV of the electron transport chain and promotes the formation of disulfide bonds in the CHCHD4 chaperone molecule. Impaired activity of this molecule underlies mitochondrial dysfunction, one of the key pathological changes in patients with type 2 diabetes mellitus.