The antioxidant and membrane-stabilizing properties of 1-(4-substituted phenyl)-2h-(phenyl)-3-aminopropan-1-ol hydrochlorides in vitro

In vitro model systems were used to study the antioxidant and membrane-stabilizing properties of 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides. These secondary aminopropanols, whose synthesis is first reported here, were found not to have any significant antioxidant or antiradical activity either in an ascorbate-dependent Fe(II)-stimulated peroxidation system, in a method based on the spectrophotometric monitoring of decreases in the concentration of the stable radical 1,1-diphenyl-2-picrylhydrazyl, or in the photochemiluminescence analysis method. However these compounds had marked antihemolytic effects in an erythrocyte oxidative stress model. It is suggested that the new 1-(4-substituted phenyl)-2H-(phenyl)-3-aminopropan-1-ol hydrochlorides are biologically active compounds with weak antioxidant properties, capable of membrane-stabilizing actions due to interaction with the structural components of cell membranes.