A biochemical and structural analysis of genetic diversity within the HLA-A*11 subtype

被引:0
|
作者
Lenong Li
Weifeng Chen
Marlene Bouvier
机构
[1] University of Connecticut,School of Pharmacy
来源
Immunogenetics | 2005年 / 57卷
关键词
Alloreactivity; Antigen selection and presentation; HLA-A*11 alleles; Natural polymorphism; Structural analysis;
D O I
暂无
中图分类号
学科分类号
摘要
The HLA-A*11 subtype includes 17 naturally occurring variants (-A*1101 to -A*1117) distributed among different ethnic groups worldwide. At present, only HLA-A*1101 has been characterized at the molecular, structural, and immunological level. Developing similar knowledge on other HLA-A*11 alleles is highly important for bone marrow and graft transplantation. This is also important to better understand disease linkages within the HLA-A*11 subtype given that HLA-A*11 molecules are associated with resistance to acquisition of HIV-1 infection and various autoimmune diseases. To broaden our understanding of HLA-A*11 molecules, we have determined the impact of natural polymorphism on the peptide-binding properties of several HLA-A*11 molecules: -A*1103, -A*1106, -A*1108, -A*1110, -A*1111, and -A*1114. We used an approach that combines data from thermal stability studies of recombinant, soluble forms of these molecules in complex with HIV-1 peptides, together with a detailed structural analysis of the resulting HLA-A*11 molecule/peptide complexes based on crystal and molecular model structures. Our analysis shows that natural polymorphism within the HLA-A*11 subtype is distributed along the α1 and α2 helices of the peptide-binding groove, in marked contrast to the pattern of polymorphism in HLA-A*2 and HLA-B*27 subtypes. Natural polymorphism greatly altered the abilities of individual -A*11 molecules to form stable complexes with HIV-1 peptides. In comparison to -A*1101, natural polymorphism altered the peptide-presenting properties of -A*1103, -A*1108, and -A*1114 and has the potential to affect the peptide-selecting properties of -A*1106, -A*1110, and -A*1111 as well. Overall, our findings suggest that HLA-A*11 molecules may stimulate alloreactive CD8+ cytotoxic T-cell responses.
引用
收藏
页码:315 / 325
页数:10
相关论文
共 50 条
  • [41] GENETIC DIVERSITY WITHIN AND AMONG 11 JUVENILE POPULATIONS OF GREEN ALDER (ALNUS-CRISPA) IN CANADA
    BOUSQUET, J
    CHELIAK, WM
    LALONDE, M
    PHYSIOLOGIA PLANTARUM, 1987, 70 (02) : 311 - 318
  • [42] Genomic and Genetic Diversity within the Pseudomonas fluorescens Complex (vol 11, e0150183, 2016)
    Garrido-Sanz, Daniel
    Meier-Kolthoff, Jan P.
    Goeker, Markus
    Martin, Marta
    Rivilla, Rafael
    Redondo-Nieto, Miguel
    PLOS ONE, 2016, 11 (04):
  • [43] AFLP analysis of genetic diversity within Saccharum officinarum and comparison with sugarcane cultivars
    Aitken, K. S.
    Li, J. -C.
    Jackson, P.
    Piperidis, G.
    McIntyre, C. L.
    AUSTRALIAN JOURNAL OF AGRICULTURAL RESEARCH, 2006, 57 (11): : 1167 - 1184
  • [44] Genetic diversity analysis using morphological and biochemical traits in baby corn (Zea ways)
    Rashmi, Kumari
    Rani, J.
    Sahay, Sanjay
    Mandal, S. S.
    Singh, Birendra
    Sinha, Sweta
    INDIAN JOURNAL OF AGRICULTURAL SCIENCES, 2021, 91 (08): : 1226 - 1229
  • [45] Assessment of genetic and biochemical diversity of Stevia rebaudiana Bertoni by DNA fingerprinting and HPLC analysis
    Thiyagarajan, M.
    Venkatachalam, P.
    ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL, 2015, 4 (01): : 79 - 85
  • [46] Population genetic analysis indicates genetic diversity of F-virguliforme within and between sampling locations
    Wang, J.
    Jacobs, J.
    Rojas, A.
    Chilvers, M.
    PHYTOPATHOLOGY, 2014, 104 (11) : 127 - 127
  • [47] NGS typing analysis software fails to identify HLA-A*24:11N allele due to presence of homopolymer sequence
    Spinelli, A.
    Lee, M.
    Vorhaben, R.
    Lacelle, C.
    HUMAN IMMUNOLOGY, 2024, 85 : 159 - 159
  • [48] A comparative genomic analysis of HLA in the CEPH Human Genetic Diversity Project (HGDP) cell panel
    Single, R.
    Meyer, D.
    Mack, S.
    Jani, A.
    Dron, H.
    Hill, J.
    Erlich, H.
    Thomson, G.
    TISSUE ANTIGENS, 2008, 72 (03): : 263 - 263
  • [49] Diversity of HLA-A, -B, -C,-DRB1, and-DQB1 alleles and haplotypes in Kazakhstani Tatar population and genetic relatedness to other populations
    Hajjej, Abdelhafidh
    Abdrakhmanova, Saniya
    Turganbekova, Aida
    Almawi, Wassim Y.
    GENE, 2024, 896
  • [50] AFLP reveals structural details of genetic diversity within cultivated olive germplasm from the Eastern Mediterranean
    Carolyn A. Owen
    Elena-Craita Bita
    Georgios Banilas
    Shady E. Hajjar
    Vardis Sellianakis
    Uygun Aksoy
    Serra Hepaksoy
    Rony Chamoun
    Salma N. Talhook
    Ioannis Metzidakis
    Polydefkis Hatzopoulos
    Panagiotis Kalaitzis
    Theoretical and Applied Genetics, 2005, 110 : 1169 - 1176