β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

被引：0
|
作者：
Nicole M. Gaudelli
Darcie H. Long
Craig A. Townsend
机构：
[1] Johns Hopkins University,Department of Chemistry
[2] † Present address: Department of Chemistry & Chemical Biology,undefined
[3] Harvard University,undefined
[4] 12 Oxford Street,undefined
[5] Cambridge,undefined
[6] Massachusetts 02138,undefined
[7] USA.,undefined
来源：
Nature | 2015年 / 520卷
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学科分类号：
摘要：
The monocyclic β-lactam rings of the nocardicin family of antibiotics are biosynthesized by an unprecedented activity of non-ribosomal peptide synthetases, a mechanism that is distinct from the pathways to the other classes of β-lactam antibiotics.
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页码：383 / 387
页数：4
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