Comparative Plasmodium falciparum Kinetics during Treatment with Amodiaquine and Chloroquine in Children

被引：0
|
作者：
A. Sowunmi
A. G. Falade
A. A. Adedeji
A. I. Ayede
B. A. Fateye
C. O. Sowunmi
A. M. J. Oduola
机构：
[1] University of Ibadan,Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research and Training
[2] University of Ibadan,Department of Paediatrics
[3] University College Hospital,Federal Training Centre for Teachers of Health Sciences
[4] University College Hospital,Clinical Pharmacology Unit
来源：
Clinical Drug Investigation | 2001年 / 21卷
关键词：
Chloroquine; Antimalarial Drug; Falciparum Malaria; Parasite Density; Fractional Reduction;
D O I：
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中图分类号：
学科分类号：
摘要：
Objectives: To examine the kinetics of the disposition of Plasmodium falciparum during treatment with amodiaquine, a Mannich base derivative of chloroquine and chloroquine. Additional aims were to compare P. falciparum kinetics in children in whom initial treatment with chloroquine failed and following re-treatment with amodiaquine, and in siblings in whom there was household clustering of falciparum infections. An important aim was to validate the kinetic method of evaluating therapeutic efficacy in a randomised trial involving the antimalarial drugs amodiaquine and chloroquine.
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页码：371 / 381
页数：10
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