A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial

被引：0
|
作者：
Keisha Smith
Amy Pace
Stephan Ortiz
Shamsah Kazani
Scott Rottinghaus
机构：
[1] Alexion Pharmaceuticals,Medical Writing
[2] Alexion Pharmaceuticals,Quantitative Sciences
[3] Alexion Pharmaceuticals,Clinical Pharmacology
[4] Alexion Pharmaceuticals,Department of Clinical Development Sciences
[5] Inc.,undefined
来源：
Trials | / 21卷
关键词：
COVID-19; severe acute respiratory distress syndrome coronavirus 2; lung injury; acute respiratory distress syndrome; respiratory distress syndrome; severe pneumonia; severe acute respiratory syndrome; acute pneumonia; viral; ravulizumab; antibodies; monoclonal; humanized; complement; complement inhibitor; Ultomiris; hospitalization; randomized controlled study; adult;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial
    Ava Ziaei
    Parivash Davoodian
    Habib Dadvand
    Omid Safa
    Soheil Hassanipour
    Mahmoud Omidi
    Moein Masjedi
    Fahime Mahmoudikia
    Bahareh Rafiee
    Mohammad Fathalipour
    Trials, 21
  • [32] Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial
    Panpan Liu
    Zhijun Huang
    Mingzhu Yin
    Chun Liu
    Xiang Chen
    Pinhua Pan
    Yehong Kuang
    Trials, 21
  • [33] Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial
    Liu, Panpan
    Huang, Zhijun
    Yin, Mingzhu
    Liu, Chun
    Chen, Xiang
    Pan, Pinhua
    Kuang, Yehong
    TRIALS, 2020, 21 (01)
  • [34] Efficacy and safety of nelfinavir in asymptomatic and mild COVID-19 patients: a structured summary of a study protocol for a multicenter, randomized controlled trial
    Naoki Hosogaya
    Taiga Miyazaki
    Yuri Fukushige
    Sachiko Takemori
    Shinpei Morimoto
    Hiroshi Yamamoto
    Makoto Hori
    Tomoya Kurokawa
    Yohei Kawasaki
    Michiko Hanawa
    Yasuhisa Fujii
    Hideki Hanaoka
    Shingo Iwami
    Koichi Watashi
    Satoshi Yamagoe
    Yoshitsugu Miyazaki
    Takaji Wakita
    Koichi Izumikawa
    Katsunori Yanagihara
    Hiroshi Mukae
    Shigeru Kohno
    Trials, 22
  • [35] Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial
    Declercq, Jozefien
    Bosteels, Cedric
    Van Damme, Karel
    De Leeuw, Elisabeth
    Maes, Bastiaan
    Vandecauter, Ans
    Vermeersch, Stefanie
    Delporte, Anja
    Demeyere, Benedicte
    Vuylsteke, Marnik
    Lalla, Marianna
    Smart, Trevor
    Detalle, Laurent
    Bouw, Rene
    Streffer, Johannes
    Degeeter, Thibo
    Vergotte, Marie
    Guisez, Tanguy
    Van Braeckel, Eva
    Van der Straeten, Catherine
    Lambrecht, Bart N.
    TRIALS, 2020, 21 (01)
  • [36] Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial
    Jozefien Declercq
    Cedric Bosteels
    Karel Van Damme
    Elisabeth De Leeuw
    Bastiaan Maes
    Ans Vandecauter
    Stefanie Vermeersch
    Anja Delporte
    Bénédicte Demeyere
    Marnik Vuylsteke
    Marianna Lalla
    Trevor Smart
    Laurent Detalle
    René Bouw
    Johannes Streffer
    Thibo Degeeter
    Marie Vergotte
    Tanguy Guisez
    Eva Van Braeckel
    Catherine Van Der Straeten
    Bart N. Lambrecht
    Trials, 21
  • [37] The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19
    Atmowihardjo, Leila
    Schippers, Job R.
    Bartelink, Imke H.
    Bet, Pierre M.
    van Rein, Nienke
    Purdy, Keith
    Cavalla, David
    Comberiati, Valerie
    McElroy, Andrew
    Snape, Sue D.
    Bogaard, Harm Jan
    Heunks, Leo
    Juffermans, Nicole
    Schultz, Marcus
    Tuinman, Pieter R.
    Bos, Lieuwe D. J.
    Aman, Jurjan
    TRIALS, 2022, 23 (01)
  • [38] Evaluation of the efficacy and safety of recombinant erythropoietin on the improvement of hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial
    Hamid Reza Samimagham
    Mehdi Hassani Azad
    Dariush Hooshyar
    Maryam Haddad
    Mohsen Arabi
    Mitra KazemiJahromi
    Trials, 22
  • [39] The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19
    Leila Atmowihardjo
    Job R. Schippers
    Imke H. Bartelink
    Pierre M. Bet
    Nienke van Rein
    Keith Purdy
    David Cavalla
    Valérie Comberiati
    Andrew McElroy
    Sue D. Snape
    Harm Jan Bogaard
    Leo Heunks
    Nicole Juffermans
    Marcus Schultz
    Pieter R. Tuinman
    Lieuwe D. J. Bos
    Jurjan Aman
    Trials, 23
  • [40] Evaluation of the efficacy and safety of recombinant erythropoietin on the improvement of hospitalised COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial
    Samimagham, Hamid Reza
    Azad, Mehdi Hassani
    Hooshyar, Dariush
    Haddad, Maryam
    Arabi, Mohsen
    KazemiJahromi, Mitra
    TRIALS, 2021, 22 (01)
12345