Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases

被引：0
|
作者：
Dorothea M. Heuberger
Reto A. Schuepbach
机构：
[1] Institute of Intensive Care Medicine,Surgical Research Division
[2] University Hospital Zurich,undefined
[3] University of Zurich,undefined
[4] University Hospital Zurich,undefined
[5] University of Zurich,undefined
来源：
Thrombosis Journal | / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecular targets, protease-activated receptors (PARs) are abundantly recognized for their roles in the development of chronic inflammatory diseases. In particular, several inflammatory effects are directly mediated by the sensing of proteolytic activity by PARs.
引用
收藏
相关论文
共 28 条
  • [21] Expression of protease-activated receptors (PARs) in OLN-93 oligodendroglial cells and mechanism of PAR-1-induced calcium signaling
    Wang, Y
    Richter-Landsberg, C
    Reiser, G
    NEUROSCIENCE, 2004, 126 (01) : 69 - 82
  • [22] Mechanisms of pruritus: Potential relationship between IL-31, IFN-γ, cathepsins and protease-activated receptors
    Sun, Y.
    Reddy, V. B.
    Lerner, E. A.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 : S20 - S20
  • [23] Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch
    Tsagareli, Merab G.
    Follansbee, Taylor
    Carstens, Mirela Iodi
    Carstens, Earl
    PHARMACEUTICALS, 2023, 16 (12)
  • [24] Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs):: a novel role for PAR-4 as opposed to PAR-1
    Kawabata, A
    Kuroda, R
    Kuroki, N
    Nishikawa, H
    Kawai, K
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (03) : 578 - 584
  • [25] Protease-Activated Receptor-4 (PAR4) Activation: Evidences for Its Role and Activation in the Pathogenesis of Colitis and in Inflammatory Bowel Diseases
    Rousset, Perrine
    Cenac, Nicolas
    Balz-Hara, Daniela
    Asfaha, Samuel
    Ferraz, Jose G.
    Beck, Paul L.
    Panaccione, Remo
    Selves, Janick
    Alric, Laurent
    Vinel, Jean-Pierre
    Vergnolle, Nathalie
    GASTROENTEROLOGY, 2009, 136 (05) : A110 - A110
  • [26] Protease-activated receptors (PAR)-1 and-3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis
    Wygrecka, Malgorzata
    Didiasova, Miroslava
    Berscheid, Sebastian
    Piskulak, Katarzyna
    Taborski, Brigitte
    Zakrzewicz, Dariusz
    Kwapiszewska, Grazyna
    Preissner, Klaus T.
    Markart, Philipp
    THROMBOSIS AND HAEMOSTASIS, 2013, 110 (02) : 295 - 307
  • [27] Protease-activated receptor (PAR), a novel family of G protein-coupled seven trans-membrane domain receptors: Activation mechanisms and physiological roles
    Kawabata, A
    Kuroda, R
    JAPANESE JOURNAL OF PHARMACOLOGY, 2000, 82 (03): : 171 - 174
  • [28] Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling
    Poole, Daniel P.
    Amadesi, Silvia
    Veldhuis, Nicholas A.
    Abogadie, Fe C.
    Lieu, TinaMarie
    Darby, William
    Liedtke, Wolfgang
    Lew, Michael J.
    McIntyre, Peter
    Bunnett, Nigel W.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (08) : 5790 - 5802
123