The role of macrophage migration inhibitory factor in maintaining the immune privilege at the fetal–maternal interface

被引：1
|
作者：
Paola Viganò
Marcella Cintorino
Frederick Schatz
Charles J. Lockwood
Felice Arcuri
机构：
[1] University of Milan and Istituto Auxologico Italiano,II Department of Obstetrics and Gynecology
[2] University of Siena—School of Medicine,Department of Human Pathology and Oncology, Section of Pathology
[3] Yale University School of Medicine,Department of Obstetrics, Gynecology and Reproductive Sciences
来源：
Seminars in Immunopathology | 2007年 / 29卷
关键词：
MIF; Pregnancy; Immunosuppression; Uterine NK cells; Decidual macrophages;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the innate and adaptive immunity affecting the response and behavior of macrophages and lymphocytes. MIF is also implicated in other fundamental cellular processes including angiogenesis and cell proliferation. Several studies examined the expression of MIF in reproductive organs and tissues and its involvement in different aspects of human and animal reproduction. The goal of this review was to summarize these findings and discuss, in particular, the role of MIF in the maintenance of the immune privilege at the human fetal–maternal interface.
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