A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn

被引：0
|
作者：
Florence Hallouin
Caroline Goupille
Jézabel Rocher
Jacques Le Pendu
机构：
[1] INSERM U419,
[2] Institut de Biologie,undefined
来源：
Glycoconjugate Journal | 1999年 / 16卷
关键词：
vaccination; Sialyl-Tn antigen; rat model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.
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页码：681 / 684
页数：3
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