A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn

被引：0
|
作者：
Florence Hallouin
Caroline Goupille
Jézabel Rocher
Jacques Le Pendu
机构：
[1] INSERM U419,
[2] Institut de Biologie,undefined
来源：
Glycoconjugate Journal | 1999年 / 16卷
关键词：
vaccination; Sialyl-Tn antigen; rat model;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.
引用
收藏
页码：681 / 684
页数：3
相关论文
共 50 条
  • [1] A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn
    Hallouin, F
    Goupille, C
    Rocher, J
    Le Pendu, J
    GLYCOCONJUGATE JOURNAL, 1999, 16 (11) : 681 - 684
  • [2] Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
    Loureiro, Liliana R.
    Carrascal, Myelene A.
    Barbas, Ana
    Ramalho, Jose S.
    Novo, Carlos
    Delannoy, Philippe
    Videira, Paula A.
    BIOMOLECULES, 2015, 5 (03): : 1783 - 1809
  • [3] EXPRESSION OF TN AND SIALYL-TN ANTIGENS IN TUMOR-TISSUES OF THE OVARY
    INOUE, M
    TON, S
    OGAWA, H
    TANIZAWA, O
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1991, 96 (06) : 711 - 716
  • [4] Tn and Sialyl-Tn antigens in canine gastric tissues
    Flores, Ana R.
    Lemos, Isabel
    Rema, Alexandra
    Taulescu, Marian
    Seixas, Fernanda
    Reis, Celso A.
    Gartner, Fatima
    Amorim, Irina
    VETERINARY AND COMPARATIVE ONCOLOGY, 2020, 18 (04) : 615 - 625
  • [5] Expression of sialyl-Tn, Tn and T antigens in primary liver cancer
    Sasaki, M
    Yamato, T
    Nakanuma, Y
    PATHOLOGY INTERNATIONAL, 1999, 49 (04) : 325 - 331
  • [6] Tn and sialyl-Tn antigens as potential prognostic markers in human ovarian carcinoma
    Ogawa, H
    Ghazizadeh, M
    Araki, T
    GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1996, 41 (04) : 278 - 283
  • [7] Regulation Of Tumor Microenvironment By Tumor Associated Sialyl-Tn Antigen On Integrin
    Takamiya, R.
    Takamatsu, S.
    Angata, T.
    Takahashi, M.
    Kuroki, Y.
    Taniguchi, N.
    Ohtsubo, K.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
  • [8] Expression of Tn and sialyl-Tn antigens in the neoplastic transformation of uterine cervical epithelial cells
    Terasawa, K
    Furumoto, H
    Kamada, M
    Aono, T
    CANCER RESEARCH, 1996, 56 (09) : 2229 - 2232
  • [9] Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers
    Ju, Tongzhong
    Wang, Yingchun
    Aryal, Rajindra P.
    Lehoux, Sylvain D.
    Ding, Xiaokun
    Kudelka, Matthew R.
    Cutler, Christopher
    Zeng, Junwei
    Wang, Jianmei
    Sun, Xiaodong
    Heimburg-Molinaro, Jamie
    Smith, David F.
    Cummings, Richard D.
    PROTEOMICS CLINICAL APPLICATIONS, 2013, 7 (9-10) : 618 - 631
  • [10] Tumor associated carbohydrate antigens in prostatic adenocarcinoma (PAC): Correlation of sialyl-Tn with malignant phenotype.
    Kristo, Silva
    Brnakova, Zuzana
    Goldman, Radoslav
    Wei, Renhuizi
    Chahine, Joeffrey J.
    Ko, Kyungmin
    Prendergast, Jillian M.
    Dransfield, Daniel T.
    Kallakury, Bhaskar
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
12345