Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

被引：0
|
作者：
Mingfeng Liao
Yang Liu
Jing Yuan
Yanling Wen
Gang Xu
Juanjuan Zhao
Lin Cheng
Jinxiu Li
Xin Wang
Fuxiang Wang
Lei Liu
Ido Amit
Shuye Zhang
Zheng Zhang
机构：
[1] Institute for Hepatology,Department for Infectious Diseases
[2] National Clinical Research Center for Infectious Disease,Department of Immunology
[3] Shenzhen Third People’s Hospital,undefined
[4] Shenzhen Third People’s Hospital,undefined
[5] The Second Affiliated Hospital,undefined
[6] School of Medicine,undefined
[7] Southern University of Science and Technology,undefined
[8] Weizmann Institute of Science,undefined
[9] Shanghai Public Health Clinical Center,undefined
[10] Fudan University,undefined
来源：
Nature Medicine | 2020年 / 26卷
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学科分类号：
摘要：
Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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页码：842 / 844
页数：2
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