Non-Polarized Secretion of Mouse Interferon-β from Gene-Transferred Human Intestinal Caco-2 Cells

被引：0
|
作者：
Kenji Kawabata
Mayumi Kondo
Yoshihiko Watanabe
Yoshinobu Takakura
Mitsuru Hashida
机构：
[1] Kyoto University,Department of Drug Delivery Research, Faculty of Pharmaceutical Sciences
[2] Kyoto University,Department of Molecular Microbiology, Faculty of Pharmaceutical Sciences
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
gene transfer; interferon-β; Caco-2 cells; non-polarized secretion; gene therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The intestinal epithelium is considered to be a feasible target for somatic gene therapy. To this end, Caco-2 cells derived from human colon carcinoma were transfected with a mouse interferon-β (IFN-β) expression vector and several stable sublines were established; this hetero-specific cytokine allows unexpected cellular effects to be avoided. Using the highest mouse IFN-β-producing sublines, the mode of IFN secretion was examined.
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页码：483 / 485
页数：2
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