To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

被引：0

作者：

Sebastian Boeltz

Poorya Amini

Hans-Joachim Anders

Felipe Andrade

Rostyslav Bilyy

Simon Chatfield

Iwona Cichon

Danielle M. Clancy

Jyaysi Desai

Tetiana Dumych

Nishant Dwivedi

Rachael Ann Gordon

Jonas Hahn

Andrés Hidalgo

Markus H. Hoffmann

Mariana J. Kaplan

Jason S. Knight

Elzbieta Kolaczkowska

Paul Kubes

Moritz Leppkes

Angelo A. Manfredi

Seamus J. Martin

Christian Maueröder

Norma Maugeri

Ioannis Mitroulis

Luis E. Munoz

Daigo Nakazawa

Indira Neeli

Victor Nizet

Elmar Pieterse

Marko Z Radic

Christiane Reinwald

Konstantinos Ritis

Patrizia Rovere-Querini

Michal Santocki

Christine Schauer

Georg Schett

Mark Jay Shlomchik

Hans-Uwe Simon

Panagiotis Skendros

Darko Stojkov

Peter Vandenabeele

Tom Vanden Berghe

Johan van der Vlag

Ljubomir Vitkov

Maren von Köckritz-Blickwede

Shida Yousefi

Alexander Zarbock

Martin Herrmann

机构：

[1] Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen,Department of Internal Medicine 3

[2] University of Bern, Rheumatology and Immunology

[3] Klinikum der Universität München,Institute of Pharmacology

[4] Johns Hopkins University School of Medicine,Medizinische Klinik und Poliklinik IV

[5] Danylo Halytsky Lviv National Medical University,Division of Rheumatology

[6] Walter and Eliza Hall Institute,Inflammation Division

[7] Jagiellonian University,Department of Experimental Hematology, Institute of Zoology and Biomedical Research

[8] University of Gent,VIB

[9] Brigham and Women’s Hospital,UGent Center for Inflammation Research

[10] Harvard Medical School,Division of Rheumatology, Immunology and Allergy, Department of Medicine

[11] University of Pittsburgh School of Medicine,Department of Immunology

[12] Fundación Centro Nacional de Investigaciones Cardiovasculares (CNIC) Carlos III,Department of Cell and Developmental Biology

[13] Ludwig Maximilians University,Institute for Cardiovascular Prevention

[14] National Institute of Arthritis and Musculoskeletal and Skin Diseases,Systemic Autoimmunity Branch

[15] National Institutes of Health,Division of Rheumatology

[16] University of Michigan,Snyder institute of Chronic Diseases

[17] University of Calgary,Department of Medicine 1 – Gastroenterology, Pulmonology and Endocrinology, Universitätsklinikum Erlangen

[18] Friedrich-Alexander-University Erlangen-Nürnberg (FAU),Molecular Cell Biology Laboratory, Department of Genetics

[19] Università Vita Salute San Raffaele and IRCCS Ospedale San Raffaele,Laboratory of Molecular Hematology, Department of Medicine

[20] The Smurfit Institute,First Department of Internal Medicine, University Hospital of Alexandroupolis

[21] Trinity College,Department of Microbiology, Immunology and Biochemistry

[22] Democritus University of Thrace,Department of Nephrology, Radboud Institute for Molecular Life Sciences

[23] Democritus University of Thrace,Department of Clinical Immunology and Allergology

[24] University of Tennessee Health Science Center,Department of Biomedical Molecular Biology

[25] UC San Diego School of Medicine,Methusalem platform

[26] Skaggs School of Pharmacy and Pharmaceutical Sciences,Laboratory of Pathophysiology, Faculty of Biomedical Sciences

[27] UC San Diego,Department of Biosciences, Vascular & Exercise Biology Unit

[28] Radboud University Medical Center,Periodontology and Preventive Dentistry

[29] Sechenov University,Department of Physiological Chemistry & Research Center for Emerging Infections and Zoonosis (RIZ)

[30] Ghent University,undefined

[31] Ghent University,undefined

[32] University of Antwerp,undefined

[33] University of Salzburg,undefined

[34] Saarland University,undefined

[35] University of Veterinary Medicine Hannover,undefined

[36] University of Münster,undefined

[37] Department of Anesthesiology,undefined

[38] Intensive Care and Pain Medicine,undefined

来源：

Cell Death & Differentiation | 2019年 / 26卷

关键词：

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中图分类号：

学科分类号：

摘要：

Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.

引用

页码：395 / 408

页数：13

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