Pyrrolopyrimidines. 4. A convenient method for the production of 6-(2-aminovinyl)-5-nitropyrimidines and their transformation into pyrrolo[3,2-d]pyrimidines

被引:0
|
作者
Tkachenko Yu.N. [1 ]
Tsupak E.B. [1 ]
Pozharskii A.F. [1 ]
机构
[1] Rostov State University, Rostov-on-Don
关键词
Pyrrolo[3,2-d]pyrimidines; Secondary amines; Triethyl orthoformiate; Uracils;
D O I
10.1007/BF02256868
中图分类号
O62 [有机化学]; TQ [化学工业];
学科分类号
070303 ; 0817 ; 081704 ;
摘要
A convenient method is proposed for the production of 6-(2- aminovinyl)pyrimidine-2,4-diones, involving the reaction of 6-methyluracils with triethyl orthoformiate and secondary amines.
引用
收藏
页码:307 / 310
页数:3
相关论文
共 50 条
  • [41] THE CHEMISTRY OF 5-HYDROXY-6-(HYDROXYALKYL)URACILS - SYNTHESIS OF SPIRO[PYRIMIDINE-4,2'-PYRANO[3,2-D]PYRIMIDINES]
    SASSON, IM
    GAGNIER, RP
    OTTER, BA
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (03) : 753 - 757
  • [42] Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1,4]diazepine derivatives as potent EGFR/CDK2 inhibitors
    Belal, Amany
    Gawad, Nagwa M. Abdel
    Mehany, Ahmed B. M.
    Abourehab, Mohammed A. S.
    Elkady, Hazem
    Al-Karmalawy, Ahmed A.
    Ismael, Ahmed S.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 1884 - 1902
  • [43] Synthesis, characterization, and biological activities of some novel thienylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and related heterocycles
    Abuelhassan, Suzan
    Bakhite, Etify A. -G.
    Abdel-Rahman, Abdu E.
    El-Mahdy, Ahmed F. M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 58 (09) : 1784 - 1801
  • [44] Efficient Synthesis and Characterization of Novel Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and Their Fused [1,2,4]triazole Derivatives
    Sanad, Sherif M. H.
    Hawass, Mahmoud A. E.
    Ahmed, Ahmed A. M.
    Elneairy, Mohamed A. A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (12) : 2823 - 2833
  • [45] Synthesis of Derivatives of Cyclopenta[4',5']Pyrido-[3',2':4,5]Thieno[3,2-d]Pyrimidines and Pyrimido[5',4':2,3]-Thieno[2,3-c]Isoquinolines
    E. G. Paronikyan
    Sh. Sh. Dashyan
    A. S. Noravyan
    N. S. Minasyan
    Chemistry of Heterocyclic Compounds, 2014, 50 : 1188 - 1194
  • [46] Synthesis of Derivatives of Cyclopenta[4',5']Pyrido-[3',2':4,5]Thieno[3,2-d]Pyrimidines and Pyrimido[5',4':2,3]-Thieno[2,3-c]Isoquinolines
    Paronikyan, E. G.
    Dashyan, Sh. Sh.
    Noravyan, A. S.
    Minasyan, N. S.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 50 (08) : 1188 - 1194
  • [47] Catalytic hydrogenation causes C-benzyl bond cleavage in 6-amino-7,7-dibenzyl-2,4-dimethoxy-7H-pyrrolo[3,2-d]pyrimidine:: An example indicating novel route to 6-amino-7-benzyl-5H-pyrrolo-[3,2-d]pyrimidines and related compounds
    Otmar, M
    Masojídková, M
    Budesínsky, M
    Holy, A
    TETRAHEDRON, 1998, 54 (12) : 2931 - 2940
  • [48] Multistep synthesis of pyrido[3′,2′:4,5]pyrrolo[3,2-d][1,3]oxazin-4(5H)-one from 2-aminonicotinonitriles
    Kanth, SR
    Maitraie, D
    Reddy, GV
    Narsaiah, B
    Rao, PS
    HETEROCYCLES, 2005, 65 (06) : 1415 - +
  • [49] Synthesis and neurotropic activity of 2,4-disubstituted pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d]pyrimidines
    Paronikyan, E. G.
    Dashyan, Sh. Sh.
    Noravyan, A. S.
    Dzhagatspanyan, I. A.
    Paronikyan, R. G.
    Nazaryan, I. M.
    Akopyan, A. G.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2015, 41 (06) : 663 - 669
  • [50] Synthesis and neurotropic activity of 2,4-disubstituted pyrano[4',3':4,5]pyrido[2,3-b]thieno[3,2-d]pyrimidines
    E. G. Paronikyan
    Sh. Sh. Dashyan
    A. S. Noravyan
    I. A. Dzhagatspanyan
    R. G. Paronikyan
    I. M. Nazaryan
    A. G. Akopyan
    Russian Journal of Bioorganic Chemistry, 2015, 41 : 663 - 669