Epistatic Quantitative Trait Loci for Alcohol Preference in Mice

被引：0
|
作者：
José R. Fernández
Lisa M. Tarantino
Scott M. Hofer
George P. Vogler
Gerald E. McClearn
机构：
[1] St. Luke's-Roosevelt Hospital Center,Obesity Research Center
[2] The Pennsylvania State University,Center for Developmental and Health Genetics
[3] The Pennsylvania State University,Center for Developmental and Health Genetics
[4] Novartis Research Foundation,Genomics Institute of the
[5] The Pennsylvania State University,Department of Human Development and Family Studies
来源：
Behavior Genetics | 2000年 / 30卷
关键词：
Epistasis; QTL; alcohol consumption; gene interaction; mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alcohol consumption is a complex trait, responding to the influence of various genes and environmental influences acting in a quantitative fashion. Various studies in alcohol consumption processes have identified quantitative trait locus (QTL) regions across the mouse genome that appear to contribute to this phenotype. The purpose of this study was to examine the influence of interactions between alleles at different loci, a phenomenon known as epistasis, on previously identified QTLs for alcohol consumption in mice. A multiple regression model was developed and applied to test for the significance of the interaction between two QTLs and to quantify this interaction. Our results indicate the presence of epistasis between loci on mouse chromosomes 2 and 3 accounting for 7-8% of the variation in alcohol preference, respectively.
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页码：431 / 437
页数：6
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