CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer’s disease

被引：0
|
作者：
Alan J. Lerner
Steven E. Arnold
Erin Maxfield
Aaron Koenig
Maria E. Toth
Brooke Fortin
Natalia Mast
Bianca A. Trombetta
John Denker
Andrew A. Pieper
Curtis Tatsuoka
Sangeetha Raghupathy
Irina A. Pikuleva
机构：
[1] Brain Health and Memory Center,Department of Neurology
[2] Neurological Institute,Alzheimer’s Clinical and Translational Research Unit
[3] University Hospitals Cleveland Medical Center,Department of Ophthalmology and Visual Sciences
[4] Case Western Reserve University,Harrington Discovery Institute
[5] Massachusetts General Hospital,Department of Psychiatry
[6] Case Western Reserve University,Institute for Transformative Molecular Medicine, School of Medicine
[7] University Hospitals Cleveland Medical Center,Department of Population and Quantitative Health Sciences
[8] Case Western Reserve University,undefined
[9] Geriatric Psychiatry,undefined
[10] GRECC,undefined
[11] Louis Stokes Cleveland VA Medical Center,undefined
[12] Case Western Reserve University,undefined
[13] Case Western Reserve University,undefined
来源：
Alzheimer's Research & Therapy | / 14卷
关键词：
CYP46A1; Efavirenz; Alzheimer’s disease; 24-Hydroxycholesterol; Stable isotope labeling kinetics;
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