Efficacy of a chitosan tampon in the loop electrosurgical excision procedure: A prospective randomized controlled study

被引:0
|
作者
Gun Oh Chong
Yoon Hee Lee
Se Young Jeon
Hee-Young Yang
Sang-Hyun An
机构
[1] Department of Obstetrics and Gynecology,
[2] School of Medicine,undefined
[3] Kyungpook National University,undefined
[4] Department of Obstetrics and Gynecology,undefined
[5] Kyungpook National University Chilgok Hospital,undefined
[6] Laboratory Animal Center,undefined
[7] Daegu-Gyeongbuk Medical Innovation Foundation,undefined
来源
Scientific Reports | / 10卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
It has been reported that chitosan has a hemostatic effect and an antibiotic activity. This study aimed to evaluate the efficacy and feasibility of using a chitosan tampon (Hemoblock-Tampon) in preventing hemorrhage and enhancing wound healing after the loop electrosurgical excision procedure (LEEP).This single-blind, prospective, randomized study included 62 consecutive patients who underwent LEEP for cervical intraepithelial neoplasia. A chitosan tampon (31 patients; treatment group), or a general tampon (31 patients; control group) was applied to the uterine cervix immediately after LEEP. One patient in the treatment group declined to participate in this study. Thus, 30 patients in the treatment group and 31 patients in the control group completed this study. For objective analysis of hemorrhage in the postoperative 2 weeks, the amounts of bleeding were checked daily with a pictorial blood assessment chart. We evaluated vaginal discharge, abdominal pain, and impairment in daily living during the postoperative 2 weeks using 5 visual analogue scale questionnaires.The bleeding count was significantly lower in the treatment group than in the control group (21.37 ± 16.86 vs. 40.52 ± 16.55, p = 0.0014). The sum of the scores of the 5 questionnaires was significantly lower in the treatment group than in the control group (6.53 ± 2.84 vs. 8.59 ± 2.88, p = 0.0079). The incidence of vaginal discharge was significantly lower in the treatment group than in the control group (20.0% vs. 48.4%, p = 0.0207). According to logistic regression, only the use of chitosan tampon reduced the risk of moderate to severe vaginal bleeding 2 weeks after surgery (Odd ratio, 0.213; 95% confidence interval, 0.06–0.76; p = 0.0172). Complete healing of the uterine cervix occurred in 86.7% of patients in the treatment group and in 61.3% of patients in the control group at 4 weeks after surgery (p = 0.0255).The use of chitosan tampons can reduce hemorrhage, vaginal discharge, abdominal pain, and impairment of daily living after LEEP. Moreover, chitosan tampon may help enhance wound healing.
引用
收藏
相关论文
共 50 条
  • [31] A new approach to prevent cervical stenosis in postmenopausal women after loop electrosurgical excision procedure: a randomized controlled trial
    Jing Lin
    Yu Meng
    Yi Chen
    Zhunan Li
    Ying Xu
    Dan Wu
    Scientific Reports, 10
  • [32] Lidocaine Spray Compared With Submucosal Injection for Reducing Pain During Loop Electrosurgical Excision Procedure A Randomized Controlled Trial
    Vanichtantikul, Asama
    Charoenkwan, Kittipat
    OBSTETRICS AND GYNECOLOGY, 2013, 122 (03): : 553 - 557
  • [33] Lidocaine Spray Versus Paracervical Block During Loop Electrosurgical Excision Procedure: A Randomized Trial
    Limwatanapan, Nopporn
    Chalapati, Wadwilai
    Songthamwat, Srisuda
    Saenpoch, Surapong
    Buapaichit, Kuanoon
    Songthamwat, Metha
    JOURNAL OF LOWER GENITAL TRACT DISEASE, 2018, 22 (01) : 38 - 41
  • [34] Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial
    Rezniczek, Guenther A.
    Hecken, Julia M.
    Rehman, Sadia
    Dogan, Askin
    Tempfer, Clemens B.
    Hilal, Ziad
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2020, 223 (06) : 888.e1 - 888.e9
  • [35] Delayed Hemorrhage: A Rare Complication of Loop Electrosurgical Excision Procedure
    Felber, Randy
    Patel, Hemangi
    Skelly, Alyson
    Sobczak, Alexandria
    Campbell, Tanique
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (01)
  • [36] A simple, inexpensive device for teaching the loop electrosurgical excision procedure
    Reeves, KO
    Young, AE
    Kaufman, RH
    OBSTETRICS AND GYNECOLOGY, 1999, 94 (03): : 474 - 475
  • [37] Syringe or Mask? Loop Electrosurgical Excision Procedure Under Local or General Anesthesia: A Randomized Trial
    Rezniczek, Gunther A.
    Hecken, Julia M.
    Rehman, Sadia
    Dogan, Askin
    Tempfer, Clemens B.
    Hilal, Ziad
    OBSTETRICAL & GYNECOLOGICAL SURVEY, 2020, 75 (10) : 596 - 597
  • [38] Effects ofMusic Listening During Loop Electrosurgical Excision Procedure on Pain and Anxiety: A Randomized Trial
    Chantawong, Nopwaree
    Charoenkwan, Kittipat
    JOURNAL OF LOWER GENITAL TRACT DISEASE, 2017, 21 (04) : 307 - 310
  • [39] Loop Electrosurgical Excision Procedure and Risk of Preterm Birth Reply
    Conner, Shayna N.
    Frey, Heather A.
    Tuuli, Methodius G.
    OBSTETRICS AND GYNECOLOGY, 2014, 124 (01): : 163 - 163
  • [40] Traction suture of the cervix: A novel procedure with loop electrosurgical excision
    Bornstein, J
    Harroch, J
    Morad, E
    OBSTETRICS AND GYNECOLOGY, 2003, 102 (05): : 1063 - 1065