Synthesis of deuterium-labeled rosuvastatin calcium

被引：0
|
作者：
Lei Tian
Li Xu
Jian Li
Mei He
机构：
[1] Yangtze University,School of Petroleum Engineering
[2] Yangtze University,School of Resources and Environment
[3] Nanjing Xiaozhuang University,School of Biochemical and Environmental Engineering
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2020年 / 324卷
关键词：
Deuterium-labeled; Rosuvastatin; Hypercholesterolemia; Synthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The stable isotope-labeled rosuvastatin was requested in order to fully understand the metabolic process of rosuvastatin. An effective synthesis approach was developed for [2H4] rosuvastatin calcium. After ten steps, [2H4] rosuvastatin calcium was prepared with excellent chemical purification and isotope enrichment which can be applied as an internal standard. Moreover, this synthesis method could be useful in synthesis of other statins.
引用
收藏
页码：941 / 947
页数：6
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