Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation

被引：0
|
作者：
Jeroen W J van Heijst
Izaskun Ceberio
Lauren B Lipuma
Dane W Samilo
Gloria D Wasilewski
Anne Marie R Gonzales
Jimmy L Nieves
Marcel R M van den Brink
Miguel A Perales
Eric G Pamer
机构：
[1] Immunology Program,Department of Medicine
[2] Sloan-Kettering Institute,Department of Medicine
[3] Memorial Sloan-Kettering Cancer Center,undefined
[4] Adult Bone Marrow Transplantation Service,undefined
[5] Memorial Sloan-Kettering Cancer Center,undefined
[6] Complejo Hospitalario de Navarra,undefined
[7] Lucille Castori Center,undefined
[8] Molecular Microbiology Core Facility,undefined
[9] Memorial Sloan-Kettering Cancer Center,undefined
[10] Weill Cornell Medical College of Cornell University,undefined
[11] Infectious Diseases Service,undefined
[12] Memorial Sloan-Kettering Cancer Center,undefined
来源：
Nature Medicine | 2013年 / 19卷
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摘要：
A limited T cell receptor (TCR) repertoire after allogeneic hematopoietic stem cell transplantation can be associated with poor clinical outcomes and greater susceptibility to infections. Jeroen van Heijst and colleagues have combined 5′ RACE PCR with deep sequencing technology to provide a reproducible and quantitative measure of the recovery of TCR diversity during the first year of transplantation with three commonly used stem cell sources in patients with various hematologic malignancies.
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页码：372 / 377
页数：5
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