Wound healing activity of Origanum vulgare engineered titanium dioxide nanoparticles in Wistar Albino rats

被引：0
|
作者：
Renu Sankar
Ravishankar Dhivya
Kanchi Subramanian Shivashangari
Vilwanathan Ravikumar
机构：
[1] Bharathidasan University,Department of Biochemistry, School of Life Science
[2] Regional Forensic Science Laboratory,undefined
来源：
Journal of Materials Science: Materials in Medicine | 2014年 / 25卷
关键词：
TiO2; Wound Closure; Institutional Animal Ethic Committee; Titanium Dioxide Nanoparticles; Metal Oxide Nanoparticles;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The titanium dioxide nanoparticles (TiO2·NPs) were synthesized utilizing Origanum vulgare under room temperature. The green synthesized TiO2 NPs excitation was confirmed using UV–Vis spectrophotometer at 320 nm. Scanning electron microscopy analysis showed TiO2·NPs are spherical in shape and connected with one another. Dynamic light scattering analysis results specified high stability in nanoparticles, with an average particle size of 341 nm. Fourier transform infrared spectroscopy peaks revealed the presence of bioactive functional groups in Origanum vulgare aqueous leaf extract much needed for the TiO2·NPs formation. X-ray diffraction spectra showed the TiO2·NPs are amorphous in nature. Furthermore, the green synthesized TiO2·NPs wound healing activity was examined in the excision wound model by measuring wound closure, histopathology and protein profiling, revealed significant wound healing activity in Albino rats. In conclusion, our results bared TiO2·NPs have delivered a novel therapeutic route for wound treatment in clinical practice.
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页码：1701 / 1708
页数：7
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