Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

被引：0

作者：

Mansun Law

Toshiaki Maruyama

Jamie Lewis

Erick Giang

Alexander W Tarr

Zania Stamataki

Pablo Gastaminza

Francis V Chisari

Ian M Jones

Robert I Fox

Jonathan K Ball

Jane A McKeating

Norman M Kneteman

Dennis R Burton

机构：

[1] The Scripps Research Institute,Department of Immunology

[2] The Scripps Research Institute,Department of Molecular Biology

[3] The Scripps Research Institute,Departments of Molecular and Experimental Medicine

[4] University of Alberta,Department of Surgery

[5] 2-75 Heritage Medical Research Building,Division of Immunity and Infection

[6] Institute of Infection,undefined

[7] Immunity and Inflammation,undefined

[8] School of Molecular Medical Sciences,undefined

[9] the University of Nottingham,undefined

[10] Queen's Medical Centre,undefined

[11] Institute of Biomedical Research,undefined

[12] Medical School,undefined

[13] University of Birmingham,undefined

[14] School of Biological Sciences,undefined

[15] University of Reading,undefined

[16] Whiteknights,undefined

[17] Rheumatology Clinic,undefined

[18] Scripps Memorial Hospital,undefined

[19] Present address: Calmune Corporation,undefined

[20] Suite 130,undefined

[21] 9393 Towne Center Drive,undefined

[22] San Diego,undefined

[23] California 92121,undefined

[24] USA.,undefined

来源：

Nature Medicine | 2008年 / 14卷

关键词：

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学科分类号：

摘要：

A major problem in hepatitis C virus (HCV) immunotherapy or vaccine design is the extreme variability of the virus. We identified human monoclonal antibodies (mAbs) that neutralize genetically diverse HCV isolates and protect against heterologous HCV quasispecies challenge in a human liver–chimeric mouse model. The results provide evidence that broadly neutralizing antibodies to HCV protect against heterologous viral infection and suggest that a prophylactic vaccine against HCV may be achievable.

引用

页码：25 / 27

页数：2

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