Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models

被引:0
|
作者
Fang Chen
Min Sha
Yanyang Wang
Tijun Wu
Wei Shan
Jia Liu
Wenbo Zhou
Yunxia Zhu
Yujie Sun
Yuguang Shi
David Bleich
Xiao Han
机构
[1] Nanjing Medical University,Key Laboratory of Human Functional Genomics of Jiangsu Province
[2] University of Texas Health Science Center,Barshop Institute for Longevity and Aging Studies
[3] Rutgers New Jersey Medical School,undefined
来源
Diabetologia | 2016年 / 59卷
关键词
Beta cell; Dysfunction; Ets-1; Glucotoxicity; PDX-1;
D O I
暂无
中图分类号
学科分类号
摘要
引用
下载
收藏
页码:316 / 324
页数:8
相关论文
共 50 条
  • [1] Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent models
    Chen, Fang
    Sha, Min
    Wang, Yanyang
    Wu, Tijun
    Shan, Wei
    Liu, Jia
    Zhou, Wenbo
    Zhu, Yunxia
    Sun, Yujie
    Shi, Yuguang
    Bleich, David
    Han, Xiao
    DIABETOLOGIA, 2016, 59 (02) : 316 - 324
  • [2] Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression
    Mao, Xuhua
    Chen, Hucheng
    Tang, Junmin
    Wang, Liangliang
    Shu, Tingting
    ENDOCRINE CONNECTIONS, 2017, 6 (03): : 121 - 128
  • [3] Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast
    Ozcan, S
    Mosley, AL
    Aryal, BK
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 295 (03) : 724 - 729
  • [4] Hepatocyte nuclear factor 3 beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
    Wu, KL
    Gannon, M
    Peshavaria, M
    Offield, MF
    Henderson, E
    Ray, M
    Marks, A
    Gamer, LW
    Wright, CVE
    Stein, R
    MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (10) : 6002 - 6013
  • [5] Expression and purification of recombinant mouse Ets-1 transcription factor
    Lionneton, F
    Drobecq, H
    Soncín, F
    PROTEIN EXPRESSION AND PURIFICATION, 2001, 21 (03) : 492 - 499
  • [6] Stable expression of a transactivation defective PDX-1 mutant reduces insulin gene transcription and endogenous PDX-1 protein levels in pancreatic beta cells.
    Peshavaria, M
    Stein, R
    DIABETES, 1997, 46 : 294 - 294
  • [7] Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer
    Liu, Li
    Liu, Yuchen
    Zhang, Xintao
    Chen, Mingwei
    Wu, Hanwei
    Lin, Muqi
    Zhan, Yonghao
    Zhuang, Chengle
    Lin, Junhao
    Li, Jianfa
    Xu, Wen
    Fu, Xing
    Zhang, Qiaoxia
    Sun, Xiaojuan
    Zhao, Guoping
    Huang, Weiren
    ONCOTARGET, 2016, 7 (18) : 25125 - 25134
  • [8] Evaluation of the expression of the antral transcription factor Pdx-1 in gastric cancer
    Leys, CM
    Washington, K
    Montgomery, E
    Wright, CV
    Nomura, S
    Goldenring, JR
    GASTROENTEROLOGY, 2005, 128 (04) : A350 - A350
  • [9] Upstream stimulatory factor (USF) regulates pdx-1 gene expression in pancreatic BETA cells
    Olson, LK
    Kaytor, EN
    Towle, HC
    Qian, J
    DIABETES, 1999, 48 : A250 - A250
  • [10] Distribution and expression of pancreatic duodenal transcription factor 1 (PDX-1) in bile duct, pancreas and gastrointestinal tract mucosa
    Deng, C
    Liu, YL
    Cho, P
    Tung, M
    Silverman, JF
    MODERN PATHOLOGY, 2005, 18 : 297A - 297A