Inhibiting cell migration and cell invasion by silencing the transcription factor ETS-1 in human bladder cancer

被引：6

作者：

Liu, Li ^{[1
,2
,4
]}

Liu, Yuchen ^{[1
]}

Zhang, Xintao ^{[1
]}

Chen, Mingwei ^{[1
]}

Wu, Hanwei ^{[1
]}

Lin, Muqi ^{[1
]}

Zhan, Yonghao ^{[1
,4
]}

Zhuang, Chengle ^{[1
,4
]}

Lin, Junhao ^{[1
,4
]}

Li, Jianfa ^{[1
,4
]}

Xu, Wen ^{[1
]}

Fu, Xing ^{[1
]}

Zhang, Qiaoxia ^{[1
]}

Sun, Xiaojuan ^{[1
]}

Zhao, Guoping ^{[1
,5
]}

Huang, Weiren ^{[1
,3
]}

机构：

[1] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Key Lab Med Reprogramming Technol, Shenzhen, Peoples R China

[2] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Urol Dept, Qingyuan, Peoples R China

[3] Peking Univ, Natl Urol Canc Ctr, Inst Urol, Dept Urol,Hosp 1, Beijing 100871, Peoples R China

[4] Shantou Univ Med Coll, Shantou, Peoples R China

[5] Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 18期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

bladder cancer; ETS-1; oncogene; cell migration; cell invasion; EXPRESSION; OVEREXPRESSION; PROTOONCOGENE; METASTASIS; APOPTOSIS; MARKER; GROWTH;

D O I：

10.18632/oncotarget.7192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As one of the members of the ETS gene family, the transcription factor v-ets avian erythroblastosis virus E26 oncogene homolog 1 (ETS-1) plays key role in the regulation of physiological processes in normal cells and tumors. In this study, we aimed to investigate the relationship between the transcription factor ETS-1 and malignant phenotypes of bladder cancer. We demonstrated that ETS-1 was up-regulated in human bladder cancer tissue compared to paired normal bladder tissue. In order to evaluate the functional role of ETS-1 in human bladder cancer, vectors expressing ETS-1 shRNA and ETS-1 protein were constructed in vitro and transfected into the human bladder cancer T24 and 5637 cells. Our results showed that the transcription factor ETS-1 could promote cell migration and cell invasion in human bladder cancer, without affecting cell proliferation and apoptosis. In conclusion, ETS-1 plays oncogenic roles through inducing cell migration and invasion in human bladder cancer, and it can be used as a therapeutic target for treating human bladder cancer.

引用

页码：25125 / 25134

页数：10

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