Down-regulation of betatrophin enhances insulin sensitivity in type 2 diabetes mellitus through activation of the GSK-3β/PGC-1α signaling pathway

被引:1
|
作者
Q. Hao
A. Zheng
H. Zhang
H. Cao
机构
[1] The First People’s Hospital of Shangqiu,Department of Endocrinology
[2] Shangqiu Normal University,College of Biology and Food
来源
Journal of Endocrinological Investigation | 2021年 / 44卷
关键词
Type 2 diabetes mellitus; Insulin resistance; Betatrophin; GSK-3β/PGC-1α signaling pathway; Homeostasis model assessment of insulin resistance;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1857 / 1868
页数:11
相关论文
共 50 条
  • [41] Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway
    CHENG Long
    SHI Lu
    HE Changhao
    WANG Chen
    LV Yinglan
    LI Huimin
    AN Yongcheng
    DUAN Yuhui
    DAI Hongyu
    ZHANG Huilin
    HUANG Yan
    FU Wanxin
    SUN Weiguang
    ZHAO Baosheng
    Chinese Journal of Natural Medicines, 2023, 21 (11) : 812 - 829
  • [42] Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X
    You, Shilong
    Xu, Jiaqi
    Yin, Zeyu
    Wu, Boquan
    Wang, Pengbo
    Hao, Mingjun
    Cheng, Cheng
    Liu, Mengke
    Zhao, Yuanhui
    Jia, Pengyu
    Jiang, Hongkun
    Li, Da
    Cao, Liu
    Zhang, Xingang
    Zhang, Ying
    Sun, Yingxian
    Zhang, Naijin
    CARDIOVASCULAR DIABETOLOGY, 2023, 22 (01)
  • [43] Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X
    Shilong You
    Jiaqi Xu
    Zeyu Yin
    Boquan Wu
    Pengbo Wang
    Mingjun Hao
    Cheng Cheng
    Mengke Liu
    Yuanhui Zhao
    Pengyu Jia
    Hongkun Jiang
    Da Li
    Liu Cao
    Xingang Zhang
    Ying Zhang
    Yingxian Sun
    Naijin Zhang
    Cardiovascular Diabetology, 22
  • [44] Down-Regulation of Amyloid-β Through AMPK Activation by Inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 Cells
    Cai, Zhiyou
    Li, Benyi
    Li, Keshen
    Zhao, Bin
    JOURNAL OF ALZHEIMERS DISEASE, 2012, 29 (01) : 89 - 98
  • [45] Down-regulation of IRAK1 attenuates podocyte apoptosis in diabetic nephropathy through PI3K/Akt signaling pathway
    Zhang, Yuan
    Chen, Xiangfan
    Yuan, Li
    Zhang, Yide
    Wu, Jianhua
    Guo, Naifeng
    Chen, Xu
    Liu, Jing
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 506 (03) : 529 - 535
  • [46] Subjects with Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity
    Isabel Hernandez, Maria
    Thabit, Hood
    Burns, Nicole
    Shah, Syed
    Brema, Imad
    Hatunic, Mensud
    Finucane, Francis
    Liesa, Marc
    Chiellini, Chiara
    Naon, Deborah
    Palacin, Manuel
    Zorzano, Antonio
    Nolan, John J.
    DIABETES, 2009, 58 : A52 - A52
  • [47] Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1α/mitofusin-2 regulatory pathway in response to physical activity
    Thabit, H.
    Hernandez, M. I.
    Burns, N.
    Shah, S.
    Brema, I.
    Hatunic, M.
    Finucane, F.
    Liesa, M.
    Chiellini, C.
    Naon, D.
    Palacin, M.
    Zorzano, A.
    Nolan, J. J.
    DIABETOLOGIA, 2009, 52 : S269 - S269
  • [48] Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity
    Isabel Hernandez-Alvarez, Maria
    Thabit, Hood
    Burns, Nicole
    Shah, Syed
    Brema, Imad
    Hatunic, Mensud
    Finucane, Francis
    Liesa, Marc
    Chiellini, Chiara
    Naon, Deborah
    Zorzano, Antonio
    Nolan, John J.
    DIABETES CARE, 2010, 33 (03) : 645 - 651
  • [49] Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells
    Zhang, Hong
    Ge, Zhijuan
    Tang, Sunyinyan
    Meng, Ran
    Bi, Yan
    Zhu, Dalong
    MOLECULAR MEDICINE REPORTS, 2017, 16 (02) : 2295 - 2301
  • [50] A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
    Tao Pang
    Yun-jie Wang
    Yuan-xue Gao
    Yuan Xu
    Qiu Li
    Yu-bo Zhou
    Lei Xu
    Zhang-jian Huang
    Hong Liao
    Lu-yong Zhang
    Jian-rong Gao
    Qing Ye
    Jia Li
    Acta Pharmacologica Sinica, 2016, 37 : 741 - 752