Aggregated single-walled carbon nanotubes attenuate the behavioural and neurochemical effects of methamphetamine in mice

被引：2

作者：

Xue, Xue ^{[1
,2
]}

Yang, Jing-Yu ^{[3
]}

He, Yi ^{[4
]}

Wang, Li-Rong ^{[1
,2
,5
]}

Liu, Ping ^{[3
]}

Yu, Li-Sha ^{[3
]}

Bi, Guo-Hua ^{[4
]}

Zhu, Ming-Ming ^{[3
]}

Liu, Yue-Yang ^{[3
]}

Xiang, Rong-Wu ^{[6
]}

Yang, Xiao-Ting ^{[3
]}

Fan, Xin-Yu ^{[3
]}

Wang, Xiao-Min ^{[3
]}

Qi, Jia ^{[4
]}

Zhang, Hong-Jie ^{[7
]}

Wei, Tuo ^{[1
,2
,8
]}

Cui, Wei ^{[3
]}

Ge, Guang-Lu ^{[1
,2
,5
]}

Xi, Zheng-Xiong ^{[4
]}

Wu, Chun-Fu ^{[3
]}

Liang, Xing-Jie ^{[1
,2
,8
]}

机构：

[1] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[2] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China

[3] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

[4] NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[5] Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China

[6] Shenyang Pharmaceut Univ, Dept Biopharmaceut Informat, Shenyang 110016, Peoples R China

[7] Chinese Acad Sci, Inst Biophys, State Key Lab Biomacromol, Beijing 100101, Peoples R China

[8] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

来源：

NATURE NANOTECHNOLOGY | 2016年 / 11卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ELECTROCHEMICAL SENSORS; DOPAMINE; PLASTICITY; RECEPTORS; OXYTOCIN; COCAINE; CORTEX; REWARD;

D O I：

10.1038/NNANO.2016.23

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Methamphetamine (METH) abuse is a serious social and health problem worldwide. At present, there are no effective medications to treat METH addiction(1). Here, we report that aggregated single-walled carbon nanotubes (aSWNTs) significantly inhibited METH self-administration, METH-induced conditioned place preference and METH- or cue-induced relapse to drug-seeking behaviour in mice. The use of aSWNTs alone did not significantly alter the mesolimbic dopamine system, whereas pretreatment with aSWNTs attenuated METH-induced increases in extracellular dopamine in the ventral striatum. Electrochemical assays suggest that aSWNTs facilitated dopamine oxidation. In addition, aSWNTs attenuated METH-induced increases in tyrosine hydroxylase or synaptic protein expression. These findings suggest that aSWNTs may have therapeutic effects for treatment of METH addiction by oxidation of METH-enhanced extracellular dopamine in the striatum.

引用

页码：613 / +

页数：10

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