Pharmacokinetic Interactions with RifampicinClinical Relevance

被引：0
|
作者：
Mikko Niemi
Janne T. Backman
Martin F. Fromm
Pertti J. Neuvonen
Kari T. Kivistö
机构：
[1] University of Helsinki and Helsinki University Central Hospital,Department of Clinical Pharmacology
[2] Dr Margarete Fischer-Bosch Institut für Klinische Pharmakologie,undefined
[3] Bosch Institut für Klinische Pharmakologie,undefined
来源：
Clinical Pharmacokinetics | 2003年 / 42卷
关键词：
Verapamil; Rifampicin; Zolpidem; Propafenone; Repaglinide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The antituberculosis drug rifampicin (rifampin) induces a number of drug-metabolising enzymes, having the greatest effects on the expression of cytochrome P450 (CYP) 3A4 in the liver and in the small intestine. In addition, rifampicin induces some drug transporter proteins, such as intestinal and hepatic P-glycoprotein. Full induction of drug-metabolising enzymes is reached in about 1 week after starting rifampicin treatment and the induction dissipates in roughly 2 weeks after discontinuing rifampicin.
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页码：819 / 850
页数：31
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