Entering an era of dynamic structural biology…

被引：0
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作者：
Allen M. Orville
机构：
[1] Diamond Light Source,
[2] Research Complex at Harwell,undefined
[3] and University of Oxford,undefined
来源：
BMC Biology | / 16卷
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摘要：
A recent paper in BMC Biology presents a general method for mix-and-inject serial crystallography, to facilitate the visualization of enzyme intermediates via time-resolved serial femtosecond crystallography (tr-SFX). They apply their method to resolve in near atomic detail the cleavage and inactivation of the antibiotic ceftriaxone by a β-lactamase enzyme from Mycobacterium tuberculosis. Their work demonstrates the general applicability of time-resolved crystallography, from which dynamic structures, at atomic resolution, can be obtained.
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