Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes

被引：0
|
作者：
Yi-Sheng Yang
Xiao-Ying Li
Jie Hong
Wei-Qiong Gu
Yi-Fei Zhang
Jun Yang
Huai-Dong Song
Jia-Lun Chen
Guang Ning
机构：
[1] Shanghai Jiao-Tong University Medical School,Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine & Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui
[2] Shanghai Jiao-Tong University Medical School,Jin Hospital
来源：
Endocrine | 2007年 / 32卷
关键词：
Interleukin-18; Insulin resistance; 3T3-L1 adipocytes; Adipokines; p38 MAPK;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor α in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.
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页码：297 / 302
页数：5
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