Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes

被引：0
|
作者：
Yi-Sheng Yang
Xiao-Ying Li
Jie Hong
Wei-Qiong Gu
Yi-Fei Zhang
Jun Yang
Huai-Dong Song
Jia-Lun Chen
Guang Ning
机构：
[1] Shanghai Jiao-Tong University Medical School,Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine & Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui
[2] Shanghai Jiao-Tong University Medical School,Jin Hospital
来源：
Endocrine | 2007年 / 32卷
关键词：
Interleukin-18; Insulin resistance; 3T3-L1 adipocytes; Adipokines; p38 MAPK;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor α in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.
引用
收藏
页码：297 / 302
页数：5
相关论文
共 50 条
  • [1] Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes
    Yang, Yi-Sheng
    Li, Xiao-Ying
    Hong, Jie
    Gu, Wei-Qiong
    Zhang, Yi-Fei
    Yang, Jun
    Song, Huai-Dong
    Chen, Jia-Lun
    Ning, Guang
    [J]. ENDOCRINE, 2007, 32 (03) : 297 - 302
  • [2] Interleukin-6 enhances glucose transport in 3T3-L1 adipocytes
    Stouthard, JML
    Elferink, RPJO
    Sauerwein, HP
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 220 (02) : 241 - 245
  • [3] Naringenin inhibits glucose uptake in 3T3-L1 adipocytes
    Harmon, AW
    Patel, YM
    [J]. FASEB JOURNAL, 2003, 17 (04): : A325 - A325
  • [4] The role of calpain in glucose uptake in 3T3-L1 adipocytes
    Paul, DS
    Patel, Y
    [J]. FASEB JOURNAL, 2002, 16 (05): : A1016 - A1016
  • [5] Influenza infection disrupts glucose uptake in 3T3-L1 adipocytes
    Harmon, AW
    Beek, MA
    [J]. FASEB JOURNAL, 2006, 20 (04): : A163 - A163
  • [6] Identification of chalcone derivatives that stimulate glucose uptake in 3T3-L1 adipocytes
    Oikawa, S
    Kamei, R
    Kadokura, M
    Kitagawa, Y
    [J]. FEBS JOURNAL, 2005, 272 : 523 - 523
  • [7] Dihydrosanguinarine Enhances Glucose Uptake in Mouse 3T3-L1 Cells
    Chow, Yit-Lai
    Iwata, Yuko
    Sato, Fumihiko
    [J]. ACS OMEGA, 2017, 2 (10): : 6916 - 6925
  • [8] 2′-benzyloxychalcone derivatives stimulate glucose uptake in 3T3-L1 adipocytes
    Kamei, R
    Kadokura, M
    Kitagawa, Y
    Hazeki, O
    Oikawa, S
    [J]. LIFE SCIENCES, 2003, 73 (16) : 2091 - 2099
  • [9] 3,3-Diindolylmethane Enhances Glucose Uptake Through Activation of Insulin Signaling in 3T3-L1 Adipocytes
    Choi, Kyeong-Mi
    Yoo, Hwan-Soo
    [J]. OBESITY, 2018, 26 (07) : 1153 - 1160
  • [10] Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes
    Takahashi, Michiko
    Takahashi, Yutaka
    Takahashi, Kenichi
    Zolotaryov, Fyodor N.
    Hong, Kyoung Su
    Kitazawa, Riko
    Iida, Keiji
    Okimura, Yasuhiko
    Kaji, Hidesuke
    Kitazawa, Sohei
    Kasuga, Masato
    Chihara, Kazuo
    [J]. FEBS LETTERS, 2008, 582 (05) : 573 - 578
12345