Direct proteome profiling of the blood serum in cosmonauts after long-term space missions

被引：3
|
作者：
Pakharukova N.A. [1 ,2 ]
Pastushkova L.K. [1 ,2 ]
Samarin G.I. [1 ]
Pochuev V.I. [3 ]
Morukov B.V. [1 ]
Larina I.M. [1 ,2 ]
机构：
[1] Institute of Biomedical Problems, Moscow
[2] Russian-French Associated Laboratory CaDyWEC, Angers
[3] Gagarin Research and Test Cosmonaut Training Center, Zvezdnyi Gorodok, Moscow oblast
来源：
Human Physiology | 2014年 / 40卷 / 7期
基金：
俄罗斯基础研究基金会;
关键词：
Fibrinogen; Blood Serum; Space Mission; Proteome Profile; Proteolytic System;
D O I：
10.1134/S0362119714070196
中图分类号：
学科分类号：
摘要：
The aim of the present study was to examine the changes in the proteome profile of the blood serum in seven Russian cosmonauts after long-term space missions aboard International Space Station. Blood was sampled 45–60 days prior to and 1 and 7 days after the end of the mission. One day after the end of vmission, we found a decrease in the peaks of β2-microglobulin and apolipoprotein CI. Additionally, we revealed shifts in functioning of the proteolytic systems of the blood, which were reflected in the changes in peak areas for specific proteins, such as fibrinogen, complement C3, high-molecular-weight kininogen, inhibitor of inter-α-trypsin, and clusterin. © 2014, Pleiades Publishing, Inc.
引用
收藏
页码：713 / 717
页数：4
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