Autoimmune disorders are increasingly recognized causes of several neurological disorders leading to significant clinical disability. This article reviews recent developments in our understanding on the pathophysiology, clinical presentations, and diagnoses of selected immune-mediated neurological disorders. It also provides a brief summary of current theories on autoimmunity and the role that certain environmental factors play in the development of immune-mediated neurological disorders. Recently recognized biomarkers might play a pathogenetic role or simply serve as a diagnostic tool.
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Univ Toronto, Univ Hlth Network, Dept Med, Kremibil Res Inst, Toronto, ON, CanadaSapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy
Haroon, Nigil
Ciccia, Francesco
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Univ Campania L Vanvitelli, Dept Precis Med, Naples, ItalySapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy
Ciccia, Francesco
Breban, Maxime
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Univ Paris Saclay, Univ Versailles St Quentin, INSERM, UMR 1173, Montigny Le Bretonneux, France
Ambroise Pare Hosp, Rheumatol Div, Boulogne, France
Univ Paris Diderot, Sorbonne Paris Cite, Lab Excellence, INFLAMEX, Paris, FranceSapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy