The role of regulatory t lymphocytes in asthma pathogenesis

被引：0
|
作者：
Douglas S. Robinson
机构：
[1] National Heart and Lung Institute,Leukocyte Biology Section, Biomedical Sciences Division and Allergy and Clinical Immunology
[2] Faculty of Medicine,undefined
[3] Imperial College London,undefined
来源：
Current Allergy and Asthma Reports | 2005年 / 5卷
关键词：
Asthma; Allergic Disease; Fluticasone Propionate; Allergy Clin Immunol; House Dust Mite;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4+CD25+ regulatory T cells, and interleukin (IL)•10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.
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页码：136 / 141
页数：5
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