Synthesis and radioprotector activity of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole copolymers

被引:0
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作者
S. A. Kedik
I. V. Sakaeva
Yu. V. Kochkina (Cherta)
D. V. Eremin
A. V. Panov
V. V. Suslov
机构
[1] Lomonosov Moscow State University of Fine Chemical Technology,State Scientific Center for Drug Expertise and Control
[2] Institute of Pharmaceutical Technology,undefined
[3] Ministry of the Russian Federation for Public Health,undefined
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关键词
copolymers; -vinylpyrrolidone; 2-methyl-5-vinyltetrazole; synthesis; properties;
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摘要
Copolymers of N-vinylpyrrolidone and 2-methyl-5-vinyltetrazole with various ratios of monomer units were synthesized by radical polymerization using the injection method. The copolymerization parameters for these monomers were calculated by the Kelen―Tudos method (r1 = 14.34; r2 = 0.06) for high degrees of conversion. Copolymers with monomer-unit concentrations up to 70 ± 5 mol% were soluble in water, non-toxic, and effective as radioprotectors.
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页码:726 / 729
页数:3
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