β-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii

被引：3
|
作者：
Shi-Fei Li
Yuan-Yuan Cheng
Yu Zhang
Shun-Lin Li
Hong-Ping He
Xiao-Jiang Hao
机构：
[1] Chinese Academy of Sciences,State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany
[2] Graduate University of Chinese Academy of Sciences,undefined
来源：
Natural Products and Bioprospecting | 2012年 / 2卷 / 3期
关键词：
-carboline alkaloids; trifilines A-C; trigonoine C;
D O I：
10.1007/s13659-012-0028-x
中图分类号：
学科分类号：
摘要：
Six β-carboline alkaloids including three new ones, trifilines A-C (1–3) were isolated from Trigonostemon filipes, along with a new β-carboline alkaloid, trigonoine C (7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A (1) and B (2) showed weak anti-HIV-1 activity with EC50 values of 54.61 µg/mL and 9.75 µg/mL, along with TI (Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes. [graphic not available: see fulltext]
引用
收藏
页码：126 / 129
页数：3
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