A modified Biginelli reaction toward oxygen-bridged tetrahydropyrimidines fused with substituted 1,2,4-triazole ring

被引：0

作者：

Mustafa K. Gümüş

Nikolay Yu. Gorobets

Yuriy V. Sedash

Valentin A. Chebanov

Sergey M. Desenko

机构：

[1] Artvin Coruh University,Science

[2] SSI “Institute for Single Crystals” of National Academy of Sciences of Ukraine,Technology Research and Application Center

[3] V. N. Karazin Kharkiv National University,undefined

来源：

Chemistry of Heterocyclic Compounds | 2017年 / 53卷

关键词：

3-amino-1,2,4-triazole; benzoxadiazocine; oxygen-bridged structure; Biginelli reaction; cascade reaction; microwave-assisted synthesis; multicomponent reaction; reaction mechanism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A microwave-assisted Biginelli-like three-component condensation using salicylic aldehyde derivatives, acetone, and 5-substituted 3-amino-1,2,4-triazoles instead of the urea component results in the formation of oxygen-bridged tetrahydrotriazolopyrimidine derivatives (11,12-dihydro-5,11-methano[1,2,4]triazolo[1,5-c][1,3,5]benzoxadiazocines) in good yields and high purity. A plausible reaction mechanism for this transformation is discussed in details using literature and experimental data.

引用

页码：1261 / 1267

页数：6

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