Wnt/beta-Catenin Signaling in Glioma

被引：0
|
作者：
Kailiang Zhang
Junxia Zhang
Lei Han
Peiyu Pu
Chunsheng Kang
机构：
[1] Tianjin Medical University General Hospital,Department of Neurosurgery
[2] Tianjin Neurological Institute,Laboratory of Neuro
[3] Ministry of Education,Oncology
[4] Tianjin Key Laboratory of Injuries,Key Laboratory of Post
[5] Variations and Regeneration of Nervous System,trauma Neuro
来源：
Journal of Neuroimmune Pharmacology | 2012年 / 7卷
关键词：
Wnt; Beta-catenin; Glioma; microRNA; Crosstalk;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Extensive data have shown that Wnt/beta-catenin signaling is associated with various disease pathologies, including an important role in tumorigenesis. Here, we review the regulation of Wnt/beta-catenin signaling in glioma, with particular focus on the expression signatures of the main components in Wnt/beta-catenin signaling, the role of key factors in Wnt/beta-catenin signaling, and crosstalk with other signaling pathways. Finally, we discuss the involvement of microRNAs in Wnt/beta-catenin signaling in glioma. This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway.
引用
收藏
页码：740 / 749
页数：9
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