Rabies virus infection in mice up-regulates B7-H1 via epigenetic modifications

被引：1
|
作者：
Ojedapo C.E. [1 ,3 ]
Muhammad A. [1 ,3 ]
Kia G.S.N. [2 ,3 ]
Abarshi M.M. [1 ,3 ]
Abdulazeez M. [1 ,3 ]
Atawodi J.C. [2 ]
Kwaga J.K.P. [2 ,3 ]
机构：
[1] Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna State
[2] Department of Public Health and Preventive Medicine, Ahmadu Bello University, Zaria
[3] Africa Centre of Excellence for Neglected Tropical Diseases and Forensic Biotechnology, Ahmadu Bello University Centre, Zaria
来源：
VirusDisease | 2020年 / 31卷 / 3期
关键词：
B7-H1; DNA methylation; Histone acetylation; Promoter region; Rabies virus infection;
D O I：
10.1007/s13337-020-00588-w
中图分类号：
学科分类号：
摘要：
Rabies virus infection is an endemic disease which remains central to public health issues. The presence of epigenetics associated with the over-expression of B7-H1 in mice brain infected with rabies virus was investigated for the first time. A significant increase (p < 0.05) in mRNA level of B7-H1 as the disease progressed was observed. The percentage of methylated region was significantly (p < 0.05) higher in infected tissues relative to uninfected. DNA methyltransferase (DNMT) and histone acetylase (HAT) activities were also significantly (p < 0.05) higher in most infected brain tissues. HAT had a relatively higher proportion than DNMT when compared to the normal. Paradoxically, it can be inferred that the rabies virus uses epigenetic mechanisms as a means of manipulating host genes, as there was an increase in global DNMT and HAT activities with concomitant increase in B7-H1 promoter methylation and expression. © 2020, Indian Virological Society.
引用
收藏
页码：388 / 394
页数：6
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