HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

被引：0

作者：

Jean-Benoît Arlet

Jean-Antoine Ribeil

Flavia Guillem

Olivier Negre

Adonis Hazoume

Guillaume Marcion

Yves Beuzard

Michaël Dussiot

Ivan Cruz Moura

Samuel Demarest

Isaure Chauvot de Beauchêne

Zakia Belaid-Choucair

Margaux Sevin

Thiago Trovati Maciel

Christian Auclair

Philippe Leboulch

Stany Chretien

Luba Tchertanov

Véronique Baudin-Creuza

Renaud Seigneuric

Michaela Fontenay

Carmen Garrido

Olivier Hermine

Geneviève Courtois

机构：

[1] Laboratoire INSERM,Département de Biothérapie

[2] unité mixte de recherche 1163,undefined

[3] centre national de la recherche scientifique (CNRS) équipe de recherche labellisée 8254,undefined

[4] 24 Boulevard de Montparnasse,undefined

[5] 75015 Paris,undefined

[6] France,undefined

[7] Service de Médecine Interne,undefined

[8] Faculté de médecine Paris Descartes,undefined

[9] Sorbonne Paris-Cité et Assistance publique – Hôpitaux de Paris,undefined

[10] Hôpital Européen Georges Pompidou,undefined

[11] 15 rue Leblanc 75908 Paris,undefined

[12] France,undefined

[13] Paris Descartes-Sorbonne Paris Cité University,undefined

[14] Imagine Institute,undefined

[15] Assistance publique – Hôpitaux de Paris,undefined

[16] Hôpital Necker,undefined

[17] 24 Boulevard de Montparnasse,undefined

[18] 75015 Paris,undefined

[19] France,undefined

[20] Laboratory of Excellence GR-Ex,undefined

[21] 75015 Paris,undefined

[22] France,undefined

[23] Faculté de médecine Paris Descartes,undefined

[24] Sorbonne Paris-Cité et Assistance publique – Hôpitaux de Paris,undefined

[25] Hôpital Necker,undefined

[26] 149 rue de Sèvres 75015 Paris,undefined

[27] France,undefined

[28] Commissariat à l’énergie atomique (CEA),undefined

[29] Institute of Emerging Diseases and Innovative Therapies (iMETI),undefined

[30] 18 Route du Panorama,undefined

[31] 92260 Fontenay-aux-Roses,undefined

[32] France,undefined

[33] INSERM,undefined

[34] unité mixte de recherche 866,undefined

[35] Equipe labellisée Ligue contre le Cancer and Association pour la Recherche contre le Cancer,undefined

[36] and Laboratoire d’Excellence Lipoprotéines et santé (LipSTIC),undefined

[37] 21033 Dijon,undefined

[38] France,undefined

[39] University of Burgundy,undefined

[40] Faculty of Medicine and Pharmacy,undefined

[41] 7 boulevard Jeanne d'Arc,undefined

[42] 21033 Dijon,undefined

[43] France,undefined

[44] INSERM,undefined

[45] unité mixte de recherche 699,undefined

[46] Hôpital Bichat,undefined

[47] 46 rue Henri Huchard,undefined

[48] 75018 Paris,undefined

[49] France,undefined

[50] Faculté de médecine and Université Denis Diderot Paris VII,undefined

来源：

Nature | 2014年 / 514卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In human β-thalassaemiaerythroblasts, HSP70 is sequestered in the cytoplasm by the excess of free α-globin chains and can no longer protect the master transcriptional factor of erythropoiesis GATA-1 from caspase-3 cleavage; transduction of a nuclear-targeted HSP70 or a caspase-3 uncleavable GATA-1 mutant restored maturation of erythropoiesis.

引用

页码：242 / 246

页数：4

共 50 条

[31] Chromatin Organization By SATB1 Regulates HSP70 Induction in Early Erythropoiesis and Lost in Diamond Blackfan Anemia
Wilkes, Mark C.
Takasaki, Kaoru
Youn, Minyoung
Chae, Hee-Don
Narla, Anupama
Sakamoto, Kathleen M.
BLOOD, 2018, 132
[32] Hsp70 is a new major regulator of erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1.
Ribeil, JAX
Zermati, Y
Kersual, J
Dussiot, M
Audat, F
Pouzet, C
Valensi, F
Varet, B
Solary, E
Garrido, C
Hermine, O
BLOOD, 2004, 104 (11) : 168A - 168A
[33] PP2A Mediated AMPK Inhibition Promotes HSP70 Expression in Heat Shock Response
Wang, Ting
Yu, Qiujing
Chen, Juan
Deng, Bo
Qian, Lihua
Le, Yingying
PLOS ONE, 2010, 5 (10):
[34] Overexpression of HSP70 inhibits cofilin phosphorylation and promotes lymphocyte migration in heat-stressed cells
Simard, Jodie P.
Reynolds, Danielle N.
Kraguljac, Alan P.
Smith, Graham S. T.
Mosser, Dick D.
JOURNAL OF CELL SCIENCE, 2011, 124 (14) : 2367 - 2374
[35] Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain
Zhang, Kuan
Zhao, Tong
Huang, Xin
Liu, Zhao-hui
Xiong, Lei
Li, Ming-ming
Wu, Li-ying
Zhao, Yong-qi
Zhu, Ling-ling
Fan, Ming
CELL STRESS & CHAPERONES, 2009, 14 (04): : 407 - 415
[36] Preinduction of HSP70 promotes hypoxic tolerance and facilitates acclimatization to acute hypobaric hypoxia in mouse brain
Kuan Zhang
Tong Zhao
Xin Huang
Zhao-hui Liu
Lei Xiong
Ming-ming Li
Li-ying Wu
Yong-qi Zhao
Ling-ling Zhu
Ming Fan
Cell Stress and Chaperones, 2009, 14 : 407 - 415
[37] HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells
Lei, Ziying
Xia, Xiaohong
He, Qiaoling
Luo, Jiali
Xiong, Yan
Wang, Jin
Tang, Hongsheng
Guan, Tianpei
Tian, Yun
Xu, Songhui
Cui, Shuzhong
MOLECULAR CARCINOGENESIS, 2021, 60 (12) : 826 - 839
[38] Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting
Shiber, Ayala
Breuer, William
Brandeis, Michael
Ravid, Tommer
MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (13) : 2076 - 2087
[39] SATB1 Regulates Chromatin Organization and HSP70 Expression in Early Erythropoiesis and Is Downregulated in Models of Diamond Blackfan Anemia
Wilkes, Mark C.
Shibuya, Aya
Scanlon, Vanessa M.
Chae, Hee-Don
Narla, Anupama
Sakamoto, Kathleen M.
BLOOD, 2021, 138
[40] Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
Cho, Hyun-Soo
Shimazu, Tadahiro
Toyokawa, Gouji
Daigo, Yataro
Maehara, Yoshihiko
Hayami, Shinya
Ito, Akihiro
Masuda, Ken
Ikawa, Noriko
Field, Helen I.
Tsuchiya, Eiju
Ohnuma, Shin-ichi
Ponder, Bruce A. J.
Yoshida, Minoru
Nakamura, Yusuke
Hamamoto, Ryuji
NATURE COMMUNICATIONS, 2012, 3

← 1 2 3 4 5 →